| TLC-SERS同时检测银黄软胶囊中3种非法添加成分 |
| 投稿时间：2019-08-21 修订日期：2020-01-27 点此下载全文 |
| 引用本文：宋卫国,陆永辉,张中湖,张会敏.TLC-SERS同时检测银黄软胶囊中3种非法添加成分[J].药学实践杂志,2020,38(2):166~169 |
| 摘要点击次数: 1392 |
| 全文下载次数: 1345 |
|
| 基金项目:山东省中医药科技发展计划（2017-133），山东省食药监局发展计划类（SDFDAFZLY201808）资助 |
|
| 中文摘要:目的 建立薄层色谱-表面增强拉曼光谱（TLC-SERS）联用技术同时检测中成药银黄软胶囊中非法添加的西药化学成分双氯芬酸钠、芬布芬、盐酸罗通定。方法 将待测样品点于硅胶板，用石油醚-乙酸乙酯（3:5）进行薄层展开，在254 nm紫外光灯下进行定位检测，在分离的各个斑点处按优选的最佳条件喷加纳米银胶溶液，用表面增强拉曼光谱（SERS）进行定性鉴别。结果 本研究建立了TLC-SERS联用技术同时检测银黄软胶囊中非法添加的双氯芬酸钠、芬布芬、盐酸罗通定的方法，并确定了3种化学成分的最低检测限。结论 TLC-SERS联用技术快速、准确、灵敏度高，可同时快速检测银黄软胶囊中非法添加的双氯芬酸钠、芬布芬和盐酸罗通定3种成分。 |
| 中文关键词:银黄软胶囊 非法添加 薄层色谱-表面增强拉曼光谱 |
| |
| Simultaneously detect three illegal additive components in Yinhuang soft capsule by TLC-SERS |
|
|
| Abstract:Objective To establish a simultaneous detection of diclofenac sodium, fenbufen and rotundine hydrochloride illegally added in Yinhuang soft capsules by TLC-SERS.Methods The samples to be measured were placed on the silica gel plate, and the thin layer was developed with petroleum ether-ethyl acetate (3:5). Location detection was carried out under 254 nm ultraviolet lamp. Nano-silver colloidal solution was sprayed at each spot of separation according to the optimum conditions, and then qualitative identification was done by TLC-SERS.Results A method for simultaneous determination of diclofenac sodium, fenbufen and rotundine hydrochloride illegally added in Yinhuang soft capsule by TLC-SERS was established. And the minimum detection limits of three chemical constituents were determined.Conclusion TLC-SERS was a rapid, accurate and sensitive method for the simultaneous and rapid detection of diclofenac sodium, fenbufen and rotundine hydrochloride illegally added into Yinhuang soft capsule. |
| keywords:Yinhuang soft capsule illegal addition TLC-SERS |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
| 关闭 |
