| 丙戊酸钠基因组学的研究进展 |
| 投稿时间：2019-06-10 修订日期：2019-10-11 点此下载全文 |
| 引用本文：周浔,谭落娇,赵宏宇,高守红.丙戊酸钠基因组学的研究进展[J].药学实践杂志,2020,38(1):14~17,34 |
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| 基金项目:国家自然科学基金项目（81302856）；上海市科学技术委员会计划项目（13ZR1413800） |
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| 中文摘要:丙戊酸钠是临床常用广谱抗癫痫药物。该药治疗窗窄、代谢个体差异大，体内代谢受多种因素影响，其中，药物代谢酶的遗传多态性是影响该药代谢的重要因素。通过查阅相关文献，总结了基因组学对丙戊酸钠临床用药的影响，为丙戊酸钠临床个体化给药提供参考。 |
| 中文关键词:丙戊酸钠 基因组学 群体药代动力学 个体化治疗 |
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| Research progress of valproic acid genomics |
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| Abstract:Valproic acid is a commonly used and broad-spectrum antiepileptic drug in clinical practice with a narrow therapeutic window. Valproic acid has a great individual difference in its metabolism which is influenced by many factors. The gene polymorphism of drug metabolic enzymes is one of the critical factors. Through consulting relevant articles, the affection of genomics and clinical treatment on valproic acid clinical application were reviewed in this paper, which provided a reference for clinical individualized treatment. |
| keywords:valproic acid genomics population pharmacokinetic individual treatment |
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