| 临床药师参与晚期直肠神经内分泌瘤患者的药学服务 |
| 投稿时间：2019-05-08 修订日期：2019-10-28 点此下载全文 |
| 引用本文：赵全凤,龚玉竹,谢赣丰,夏培元,唐敏.临床药师参与晚期直肠神经内分泌瘤患者的药学服务[J].药学实践杂志,2019,37(6):559~562 |
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| 基金项目:国家自然科学基金青年科学基金项目（81802117） |
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| 中文摘要:目的 探讨临床药师在晚期直肠神经内分泌瘤患者抗肿瘤治疗中的作用。方法 临床药师参与1例晚期直肠神经内分泌瘤患者的药学服务过程中，结合患者实际情况，从用药的有效性和安全性方面提供治疗方案建议，并进行全程药学监护。结果 依维莫司可引起高血糖的严重不良反应，用药时需注意监测；阿帕替尼可作为晚期直肠神经内分泌瘤患者后线化疗的选择。结论 新型抗肿瘤药物不良反应的监护和缺乏循证药学证据的情况下，后线如何选择抗肿瘤药物，是临床药师工作的切入点，此对提高晚期直肠神经内分泌瘤患者的用药安全性和有效性方面起着重要作用。 |
| 中文关键词:晚期直肠神经内分泌瘤 依维莫司 阿帕替尼 药学服务 |
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| Clinical pharmacists involved in the pharmaceutical care of patients with advanced rectal neuroendocrine tumor |
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| Abstract:Objective To investigate the role of clinical pharmacists in anti-tumor therapy in patients with advanced rectal neuroendocrine tumors.Methods Clinical pharmacists participated in the pharmacy service of a patient with advanced rectal neuroendocrine tumor.Combined with the actual situation of the patient,the clinical pharmacist provided advice on the efficacy and safety of the medication and conducted full-course pharmaceutical care.Results Everolimus can cause serious adverse reactions of hyperglycemia and should be monitored when using drugs.Apatinib can be used as a choice for posterior chemotherapy in patients with advanced rectal neuroendocrine tumors.Conclusion In the case of monitoring the adverse effects of new anti-tumor drugs and lack of evidence-based pharmacological evidence,how to choose anti-tumor drugs in the posterior line is the entry point for clinical pharmacists' work,which plays an important role for improving the safety and efficacy of the drug use of patients with advanced rectal neuroendocrine tumors. |
| keywords:advanced rectal neuroendocrine tumor everolimus apatinib pharmaceutical services |
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