| 19F核磁共振定量法测定含氟漱口液中氟化钠的含量 |
| 投稿时间：2019-04-12 修订日期：2019-07-20 点此下载全文 |
| 引用本文：华俊杰,朱海菲,李育.19F核磁共振定量法测定含氟漱口液中氟化钠的含量[J].药学实践杂志,2019,37(6):518~520 |
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| 中文摘要:目的 建立19F核磁共振技术测定含氟漱口液中氟化钠含量的方法。方法 采用19F核磁共振技术，以三氟乙酸作为内标物，使用300MHz核磁共振波谱仪，在25℃下采集样品的19F核磁共振谱，建立内标标准曲线，用于氟化钠定量分析。结果 氟化钠在0.1~0.8 mg/ml范围内，线性关系良好，回归方程为A=1.1392C-0.0013，r=0.99995；低、中、高3个浓度的平均回收率分别为99.36%、99.31%、99.65%，RSD分别为0.51%、0.35%、0.54%，含氟漱口液中氟化钠的平均含量为99.30%。结论 研究建立的19F核磁共振方法准确度、精密度较好，能够快速、准确地测定含氟漱口液中氟化钠的含量。 |
| 中文关键词:19F-NMR 氟化钠 含量测定 定量核磁共振 |
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| Determination of sodium fluoride in fluoride-containing mouthwash by 19F-NMR |
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| Abstract:Objective To establish a method for the determination of sodium fluoride in fluoride-containing mouthwash by 19F-NMR technique.Methods The 19F-NMR technique was used to establish the relevant standard curve with trifluoroacetic acid as the internal standard.The 19F-NMR spectrum of the sample was collected at 25℃ using a 300 MHz NMR spectrometer.Results The linear relationship of sodium fluoride was good in the range of 0.1-0.8 mg/ml.The regression equation was A=1.1392C-0.0013,r=0.99995.The average recovery of low,medium and high concentration levels were 99.36%,99.31.% and 99.65%,respectively,and RSD was 0.51%,0.35% and 0.54% respectively.The average content of sodium fluoride in the fluoride mouthwash was 99.30%.Conclusion The method was accurate and precise which could be used to determine the sodium fluoride in fluoride-containing mouthwash. |
| keywords:19F-NMR sodium fluoride determination of content standard curve |
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