| 抗疟药的剂型研究进展 |
| 投稿时间：2019-04-08 修订日期：2019-10-28 点此下载全文 |
| 引用本文：刘萍,卢光照,鲁莹,邹豪.抗疟药的剂型研究进展[J].药学实践杂志,2019,37(6):481~484 |
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| 基金项目:国家自然科学基金项目（81773278）；军队后勤科研重大项目（AWS14J011）；重大新药创制（2018ZX09J18110-004） |
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| 中文摘要:疟疾是发展中国家尤其是非洲地区所面临的传染病中的头号杀手，严重威胁人类健康。喹啉类、二氢叶酸还原酶抑制剂以及青蒿素类药物是目前治疗疟疾的主要药物，具有良好的临床应用价值，但存在溶解度差、缺乏靶向性等缺点。目前，优化抗疟疾药物剂型已成为研究的热点。现对抗疟药的各种优化剂型，例如固体分散体、环糊精包合物、纳米粒、脂质体等进行综述。 |
| 中文关键词:疟疾 抗疟药 剂型 纳米粒 |
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| Advances in research on antimalarial dosage forms |
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| Abstract:Malaria is a critical public health problem resulting in substantial morbidity and mortality in developing countries,especially in Africa.Quinoline,dihydrofolate reductase inhibitors and artemisinin drugs are currently the main drugs for the treatment of malaria,and have good clinical application value,but have the disadvantages of poor solubility,low bioavailability and lack of targeting.To overcome these drawbacks,optimizing the anti-malarial drug dosage form has become a research hotspot at present.Various optimized dosage forms for antimalarial drugs,such as solid dispersions,cyclodextrin inclusion complexes,nanoparticles,liposomes,etc.,are now reviewed. |
| keywords:malaria antimalarials dosage forms nanoparticles |
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