| 多效防护霜的处方优化 |
| 投稿时间：2018-10-29 修订日期：2019-01-02 点此下载全文 |
| 引用本文：韩凌,樊莉,张翮,吕磊,邹豪,鲁莹.多效防护霜的处方优化[J].药学实践杂志,2019,37(2):135~140,150 |
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| 基金项目:国家科技重大专项资助项目（2018ZX09J18110-001-001） |
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| 中文摘要:目的 研制一款具有防水、防晒、防水母蜇伤的多效防护霜，并对其处方进行优化，使其具有较好的防水性能和较高的防晒指数（SPF值），同时具有适宜的黏度和较好的稳定性。方法 通过测定SPF值、关键波长和防水性能对处方中的成膜剂吡咯烷酮/十六烯共聚物（Antaron V-216）的质量分数进行优化。然后以黏度、离心稳定性和冻融稳定性为考察指标，使用星点设计-效应面法对多效防护霜中的两种乳化剂和氯化钙水溶液的质量分数进行优化。结果 当成膜剂Antaron V-216质量分数为3%时，霜剂的SPF值提升较为显著。当乳化剂月桂基聚乙二醇/聚丙二醇-18/18二甲基硅氧烷（DC5200）质量分数为0.76%，乳化剂鲸蜡基聚乙二醇/聚丙二醇-10/1二甲基硅氧烷（EM180）质量分数为2.32%，氯化钙水溶液质量分数为44.86%时，霜剂具有适宜的黏度和较好的稳定性。结论 经过优化的处方具有较高的防水性能和SPF值，黏度适宜，稳定性较好。 |
| 中文关键词:防晒剂 水母 蜇伤 防护制剂 防晒指数 效应面法 |
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| Formulation optimization for multi-purpose protective cream |
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| Abstract:Objective To develop a multi-purpose protective cream with waterproof,sunscreen and jellyfish sting protection and optimize the formulation to provide good water resistance,high SPF,suitable viscosity and good stability.Methods The mass fraction of the film former VP/Hexadecene copolymer (Antaron V-216) in the formulation was optimized through the measurement of SPF value,critical wavelength and water resistance.Based on viscosity,centrifugal stability and freeze-thaw stability,the central composite design-response surface method was used to optimize the mass fraction of two emulsifiers and CaCl2 aqueous solution in the cream.Results When the film former Antaron V-216 has a mass fraction of 3%,the SPF value of the cream is significantly increased.When the mass fraction of emulsifier lauryl PEG/PPG-18/18 methicone (DC5200) is 0.76%,the mass fraction of emulsifier cetyl PEG/PPG-10/1 dimethicone (EM180) is 2.32% and the mass fraction of CaCl2 aqueous solution is 44.86%,the cream has suitable viscosity and good stability.Conclusion The optimized formulation has high water resistance and SPF value,suitable viscosity and good stability. |
| keywords:sunscreens jellyfish nematocyst protective agent SPF response surface method |
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