| PP2C蛋白磷酸酶调控的细胞信号通路研究进展 |
| 投稿时间：2017-11-23 修订日期：2018-07-01 点此下载全文 |
| 引用本文：齐阳,许维恒,张俊平,宋洪涛.PP2C蛋白磷酸酶调控的细胞信号通路研究进展[J].药学实践杂志,2018,36(5):385~388,456 |
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| 中文摘要:2C类蛋白磷酸酶是蛋白磷酸酶家族的重要成员，可以对丝/苏氨酸残基特异性脱磷酸。近来研究表明，2C类蛋白磷酸酶控制着大量关键的细胞功能，如增殖、细胞周期阻滞、衰老和细胞程序性死亡、凋亡和自噬等，因而在介导机体免疫反应、衰老、神经发育及肿瘤发生发展中发挥重要的生物学作用。总结PP2C基因各亚型参与介导的重要细胞信号通路，如丝裂原活化蛋白激酶（MAPK）、磷脂酰肌醇3-激酶/丝苏氨酸蛋白激酶（PI3K/AKT）、转化生长因子-β（TGF-β）/Smads、核转录因子-κB（NF-κB）及DNA损伤应答通路，以期为阐明上述生理病理过程的分子基础和调控机制提供新的思路。 |
| 中文关键词:PP2C蛋白磷酸酶 细胞信号通路 丝裂原活化蛋白激酶 磷脂酰肌醇3-激酶/丝苏氨酸蛋白磷酸酶 转化生长因子-β/Smads 核转录因子-κB DNA损伤应答 |
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| Progress on cell signaling pathways regulated by PP2C protein phosphatases |
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| Abstract:The protein phosphatase 2C family (PP2C), belonging the protein phosphatases, is a kind of importantly specific serine/threonine dephosphatase. Recent studies show that PP2C control a lot of critical cellular functions:proliferation, cell cycle arrest, senescence and programmed cell death, apoptosis and autophagy, showing potentially biological role in regulating immune response, aging, neurogenesis and tumorigenesis. Several dominant cellular signaling pathways controlled by PP2C gene subtypes were reviewed in this paper, such as mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase(PI3K)-AKT, transforming growth factor β(TGF-β)/Smads, transcription factor nuclear factor-κB (NF-κB) and DNA-damage response pathways, which offered new ways to clarify the molecular basis and regular mechanisms for those physiological and pathological processes. |
| keywords:PP2C protein phosphatases cell signaling pathways MAPK PI3K-AKT TGF-β/Smads NF-κB DNA-damage response |
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