| 愈肠颗粒的提取工艺研究 |
| 投稿时间：2017-09-20 修订日期：2017-11-06 点此下载全文 |
| 引用本文：邵雪庆,唐晓萌,杨盟,卞俊,刘继勇.愈肠颗粒的提取工艺研究[J].药学实践杂志,2018,36(1):46~49 |
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| 基金项目:上海市科委科技支撑项目（16401901900）；上海市人才发展基金（201658）；天然药物活性组分与药效国家重点实验室开放课题（SKLNMKF201612） |
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| 中文摘要:目的 研究医院制剂愈肠颗粒的最优提取工艺。方法 以愈肠颗粒中的有效成分小檗碱、白术内酯Ⅰ的含量和浸膏得率为评价指标，采用正交试验法优选愈肠颗粒的最佳提取工艺。结果 通过正交试验的直观分析、方差分析及验证性实验，优选出其最佳提取工艺条件为：处方量药材加10倍量水提取；提取2次，每次1 h；提取液的醇沉浓度为70%。结论 该工艺操作简单方便、稳定可行，可用作愈肠颗粒的优化提取方法。 |
| 中文关键词:医院制剂 愈肠颗粒 正交试验 提取工艺 |
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| Extraction process optimization for Yuchang granules by orthogonal experiment |
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| Abstract:Objective To investigate the extraction process of Yuchang granules. Methods The extraction process was optimized by orthogonal experiment based on the content of berberine, atractylodes lactone Ⅰ and the extraction yield. Results Through the visual analysis of orthogonal experiment, the analysis of variance and the verification experiments, the optimum extraction process was obtained as follows:extracting 1 h for twice with 10 times water of medicinal herbs and the 70% ethanol depositing concentration. Conclusion This process is consistent and feasible. It is a simple and convenient method to extract Yuchang granules. |
| keywords:pharmacy preparation Yuchang granules orthogonal experiment extraction process |
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