| 玄参配方颗粒联合福辛普利治疗充血性心力衰竭的疗效观察 |
| 投稿时间：2017-01-01 修订日期：2017-04-05 点此下载全文 |
| 引用本文：钱俞君,秦春霞,孙莉莉,丁华敏,李医明,李铁军.玄参配方颗粒联合福辛普利治疗充血性心力衰竭的疗效观察[J].药学实践杂志,2017,35(3):267~269 |
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| 基金项目:浦东新区中医药事业发展专项资金"院内制剂和经验方规范化临床验证"项目（PDYNZJ2015-09） |
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| 中文摘要:目的 临床观察玄参配方颗粒联合福辛普利治疗充血性心力衰竭（CHF）的疗效。方法 60例充血性心力衰竭患者，随机分为治疗组30例和对照组30例。在常规治疗基础上，对照组给予福辛普利的治疗，治疗组给予玄参配方颗粒联合福辛普利，疗程均为90 d，评价临床疗效，测定治疗前后左室舒张末期内径（LVEDD）、左室收缩末期内径（LVESD）、左室射血分数（LVEF）和血清B型脑钠肽（BNP）的浓度。结果 治疗组和对照组的总有效率均为90%，但治疗组的显效例数大于对照组。与治疗前比较，治疗组和对照组的BNP、LVEDD和LVESD均显著降低，LVEF显著增加，差异均具有统计学意义（P<0.01）。治疗组改善心功能的程度优于对照组（P<0.05）。结论 玄参配方颗粒联合福辛普利治疗CHF有明显疗效。 |
| 中文关键词:充血性心力衰竭 玄参 福辛普利 脑钠肽 |
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| Clinical efficacy of Scrophularia ningpoensis granules combined with fosinopril for congestive heart failure |
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| Abstract:Objective To evaluate the efficacy of Scrophularia ningpoensis granules combined with fosinopril in treatment of congestive heart failure. Methods 60 congestive heart failure patients were randomly divided into 2 groups, 30 patients in the treatment group and 30 patients in the control group. Besides the conventional therapy, the control group was treated with fosinopril and the treatment group received Scrophularia ningpoensis granules plus fosinopril for 90 days. Left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular ejection fraction (LVEF) and serum B-type brain natriuretic peptide (BNP) were measured before and after treatment. Results The total effective rate in the treatment group and the control group were 90%, but significantly effective number in the treatment group was higher than the control group. The levels of BNP, LVEDD and LVESD in both groups were decreased, while LVEF was increased after the treatment. The difference was statistically significant (P<0.01). The degree of improvement of heart function in the treatment group was better than that in the control group (P<0.05). Conclusion The combination therapy of Scrophularia ningpoensis granules and fosinopril is efficacious in treating CHF. |
| keywords:congestive heart failure Scrophularia ningpoensis fosinopril brain natriuretic peptide |
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