| 肿瘤干细胞的治疗耐受机制研究进展 |
| 投稿时间：2016-02-05 修订日期：2016-06-15 点此下载全文 |
| 引用本文：曹梦雪,孙凡,林厚文.肿瘤干细胞的治疗耐受机制研究进展[J].药学实践杂志,2017,35(3):193~196,247 |
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| 基金项目:国家青年科学基金资助项目（81502936） |
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| 中文摘要:肿瘤的发病率和死亡率位居各类疾病之首，肿瘤的复发和转移是目前肿瘤治疗失败的主要原因，肿瘤治疗的失败又与肿瘤干细胞有着密切的关系。肿瘤干细胞的耐药机制一般包括以下几个方面：高表达的ABC转运蛋白介导化疗药物外排；乙醛脱氢酶的高表达与肿瘤的发病率和预后差显著相关；高效的DNA损伤修复能力；促存活通路的激活能力。笔者综合介绍肿瘤干细胞几种主要的治疗耐受机制，以期为开发新型抗肿瘤药物以及临床合理用药提供理论依据。 |
| 中文关键词:肿瘤干细胞 治疗耐受 ABC转运蛋白 乙醛脱氢酶 DNA损伤修复 促存活通路 |
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| Advance in resistance mechanism of cancer stem cells therapy |
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| Abstract:Lung cancer is the leading cause of cancer deaths worldwide. Recurrence and metastasis are the primary reasons for its poor prognosis. Growing evidence has proposed that lung cancer may be driven by cancer stem cells (CSCs), which may be responsible for the poor outcome of lung cancer. The resistance mechanisms of cancer stem cells include four aspects: high expression of the chemo-resistant efflux transporter ABC in CSCs populations, over-expression of ALDH, efficient DNA damage repair system, developmental pathway activation. The tolerance mechanism of CSCs was described to provide theoretical basis for clinical treatment and development of new anti-tumor drugs. |
| keywords:cancer stem cells therapy resistance ABC transports ALDH DNA damage repair developmental pathway activation |
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