| 胱氨酸结模体多肽的特征及其在药物设计和分子工程中的应用 |
| 投稿时间：2015-10-30 修订日期：2016-04-26 点此下载全文 |
| 引用本文：邓宇晨,顾嘉伟,聂菲,肖良.胱氨酸结模体多肽的特征及其在药物设计和分子工程中的应用[J].药学实践杂志,2016,34(6):481~484,496 |
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| 基金项目:国家自然科学基金面上项目（81470518） |
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| 中文摘要:胱氨酸结（cystine knot，CK）模体是由两对二硫键及其相连的肽链骨架形成的一个内部环以及从环中穿过的第三对二硫键组成的球形结构，广泛存在于真菌、植物、海洋软体动物、昆虫以及蜘蛛等生物的毒素多肽和蛋白质中。CK多肽结构非常稳定、生物活性多样，是一类在药物设计和分子工程研究中的理想模型分子。本文综述了抑制剂胱氨酸结（inhibitor cystine knot，ICK）多肽和环形胱氨酸结（cyclic cystine knot，CCK）多肽两类主要CK毒素的氨基酸序列、拓扑结构、排列组合、人工合成以及空间折叠等特征，并进一步阐述了其在药物设计与分子工程中的应用前景。 |
| 中文关键词:胱氨酸结 环形胱氨酸结 抑制剂胱氨酸结 Kalata B1 |
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| Cystine knot peptide's properties and its applications for drug design and molecular engineering |
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| Abstract:The cystine knot (CK) motif comprises an internal ring formed by two disulfide bonds and their connecting backbone segments which is threaded by a third disulfide bond. It is present in peptides and proteins of a variety of species, including fungi, plants, marine molluscs, insects and spiders. CK polypeptide is one of the ideal model molecules for drug design and molecular engineering research because of its stable structure and variety of bioactivities. Here we summarized the main structural features of both inhibitor cystine knot (ICK) peptide and cyclic cystine knot (CCK) peptide, including primary sequence, topology, permutation, synthesis and folding characteristics, as well as its applications on drug design and molecular engineering. |
| keywords:cystine knot cyclic cystine knot inhibitor cystine knot Kalata B1 |
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