| 花刺参中三个新的三萜皂苷类化合物 |
| 投稿时间：2015-03-13 修订日期：2016-07-01 点此下载全文 |
| 引用本文：王强,王晓华.花刺参中三个新的三萜皂苷类化合物[J].药学实践杂志,2016,34(5):431~436,454 |
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| 中文摘要:目的 研究花刺参体内的活性皂苷类成分。方法 运用硅胶、Sephadex LH-20柱色谱等方法进行分离纯化，利用IR，1H、13C NMR，MS等光谱技术鉴定其化学结构。结果 从花刺参中分离并鉴定出3个化合物，分别为3-O-[3-O-甲基-β-D-吡喃葡萄糖-（1→3）-β-D-吡喃木糖-（1→3）-β-D-吡喃葡萄糖-（1→2）-β-D-吡喃木糖]-海参烷-7，24-二烯-3β，23S-二醇，命名为variegatuside C；3-O-{3-O-甲基-β-D-吡喃葡萄糖-（1→3）-β-D-吡喃木糖-（1→4）-β-D-吡喃葡萄糖-（1→2）[β-D-吡喃葡萄糖-（1→4）]-β-D-吡喃木糖}-海参烷-8-烯-3β，23S-二醇，命名为variegatuside D；3-O-{3-O-甲基-β-D-吡喃葡萄糖-（1→3）-β-D-吡喃木糖-（1→4）-β-D-吡喃葡萄糖-（1→2）[3-O-甲基-β-D-吡喃葡萄糖-（1→3）-β-D-吡喃葡萄糖-（1→4）]-β-D-吡喃木糖}-海参烷-9-烯-3β，23S-二醇，命名为variegatuside E。结论 3个化合物均为新化合物。 |
| 中文关键词:花刺参 海参 三萜皂苷 |
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| Three new triterpene glycosides from Stichopus variegatus |
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| Abstract:Objective To study the chemical constituents from the Stichopus variegatus. Method The compounds were isolated and purified by silica gel column chromatography, Sephadex LH-20 gel filtration and recrystallization. The structures of these compounds were identified through chemical reactions and spectral analyses, such as IR,1H,13C NMR,MS. Results Three compounds were identified as 3-O-[3-O-methyl-β-D-glucopyranosyl(1→3)-β-D-xylopyranosyl(1→3)-β-D-glucopyranosyl(1→2)-β-D-xylopyranosyl]-holosta-7,24-diene-3β,23S-diol, named as variegatuside C; 3-O-{3-O-methyl-β-D-glucopy-ranosyl(1→3)-β-D-xylopyranosyl(1→4)-β-D-glucopyranosyl(1→2)[β-D-glucopyranosyl(1→4)]-β-D-xylopyranosyl-holosta-8-ene-3β,23S-diol, named as variegatuside D; 3-O-{3-O-methyl-β-D-glucopyranosyl(1→3)-β-D-xylopyranosyl(1→4)-β-D-glucopyranosyl(1→2)[3-O-methyl-β-D-glucopyranosyl(1→3)-β-D-glucopyranosyl(1→4)]-β-D-xylopyranosyl｝-holosta-9-ene-3β,23S-diol, named as variegatuside E. Conclusion All three compounds are new compounds. |
| keywords:Stichopus variegatus Semper sea cucumber triterpene glycoside |
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