| 中药及其活性成分与氯吡格雷抗血小板聚集的相互作用 |
| 投稿时间：2016-03-25 修订日期：2016-06-13 点此下载全文 |
| 引用本文：黄瑾,曾颖,唐帆,袁芳.中药及其活性成分与氯吡格雷抗血小板聚集的相互作用[J].药学实践杂志,2016,34(5):389~392,398 |
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| 基金项目:浦东新区卫生系统学科带头人培养计划（PWRd2014-11）；浦东新区示范中药药剂学科（示范中药房）建设项目（PDZYXK-2-2013003）；上海市药学会科研项目临床药学课题支持重点（2013-YY-02-16） |
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| 中文摘要:氯吡格雷是临床常用的抗血小板聚集药物，临床上常与中药制剂联合使用。加强中药及其活性成分与氯吡格雷相互作用机制的研究，对提高抗血小板聚集作用，协同改善氯吡格雷抵抗提供依据。笔者综述了国内外相关文献中药及其活性成分与氯吡格雷相互作用的研究进展。细胞色素P450代谢酶、肝羧酸酯酶、P糖蛋白是中药及其活性成分与氯吡格雷发生相互作用的主要环节，也有些中药及其活性成分在药效学方面与氯吡格雷有协同抗血小板聚集作用。 |
| 中文关键词:中药及其活性成分 氯吡格雷 抗血小板聚集 相互作用 急性冠脉综合征 缺血性脑卒中 |
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| Interaction and active components of traditional Chinese medicine with clopidogrel on platelet aggregation |
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| Abstract:Clopidogrel is commonly used as an anti-platelet aggregation drug in the clinical treatment, which is often used in combination with traditional Chinese medicine. Strengthening the study on the interaction mechanism of Chinese herbal medicine and its active components with clopidogrel, to improve the effect of anti-platelet aggregation and the therapeutic effect of clopidogrel resistance. The research progress on the interaction of Chinese herbal medicine and its active components with clopidogrel were summarized in domestic and foreign literatures. Cytochrome P450, liver carboxylesterase, P glycoprotein is a major part of the interaction of traditional Chinese medicine and its active ingredient of clopidogrel. Some active components in Chinese medicine have synergistic effect of clopidogrel on platelet aggregation. |
| keywords:traditional Chinese medicine and its active components clopidogrel platelet aggregation interaction acute coronary syndrome ischemic stroke |
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