| 双歧杆菌三联活菌胶囊辅助根除幽门螺杆菌感染临床疗效的荟萃分析 |
| 投稿时间：2015-11-16 修订日期：2016-05-10 点此下载全文 |
| 引用本文：刘留,费素娟.双歧杆菌三联活菌胶囊辅助根除幽门螺杆菌感染临床疗效的荟萃分析[J].药学实践杂志,2016,34(4):380~384 |
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| 中文摘要:目的 系统评价根除幽门螺杆菌（Helicobacter pylori， Hp）的标准三联方案与加用双歧杆菌三联活菌胶囊的标准三联方案的临床疗效和不良反应。方法 应用Stata12.0软件，对国内有关双歧杆菌三联活菌胶囊联合标准三联方案根除Hp感染的临床随机对照试验进行荟萃（Meta）分析，综合定量分析其临床治疗效果及治疗过程中的不良反应。结果 共8项随机试验纳入研究，包括1144例患者，对Hp根除率和不良反应情况分别进行Meta分析，结果显示，治疗组Hp根除率（85.91%）明显高于对照组（69.21%） （合并OR为3.07，95% CI为2.25～4.19，总体效应检验Z=7.08，P<0.01）；治疗组与对照组的不良反应发生率分别为7.58%和20.87% （合并OR为0.42，95% CI为0.29～0.61，总体效应检验Z=4.48，P<0.01），两组比较差异有统计学意义。结论 标准三联方案加用双歧杆菌三联活菌胶囊可以提高Hp的根除率，且能够减少抗Hp治疗过程中的不良反应。 |
| 中文关键词:双歧杆菌三联活菌胶囊 幽门螺杆菌根除率 荟萃分析 |
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| A Meta-analysis of Bifidobacterium viable triple capsule on Helicobacter pylori eradication during clinical therapy |
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| Abstract:Objective To evaluate the effecacy of Bifidobacterium viable triple capsule on anti-Helicobacter pylori (Hp) treatment and its adverse reactions during eradication therapy. Methods Trials on the effect of Bifidobacterium viable triple capsule on Hp eradication were analyzed by Meta-analysis with the software Stata 12.0 for comprehensive quantitative analysis of its clinical efficacy and adverse reactions during treatment. Results Eight randomly controlled trials (n=1144) were included. Pooled Hp eradication rates were 85.91% and 69.21% for patients with and without Bifidobacterium viable triple capsule respectively, with the odds ratio (OR) being 3.07 (95% CI=2.25~4.19, test for overall effect Z=7.08, P<0.01); the occurrences of total adverse reactions were 7.58% and 20.87% respectively, with the summary OR being 0.42 (95% CI=0.29~0.61, test for overall effect Z=4.48, P<0.01). The difference of the two groups was statistically significant. Conclusion Current evidence shows that Bifidobacterium viable triple capsule could increase eradication rate of anti-Hp treatment and improve adverse reactions during therapy. |
| keywords:Bifidobacterium viable triple capsule Hp eradication rate Meta-analysis |
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