| DC-CIK与结直肠癌患者预后的关系和影响因素 |
| 投稿时间：2016-04-08 修订日期：2016-05-17 点此下载全文 |
| 引用本文：操跃,杨喜晶,周福平,张迁,钱其军.DC-CIK与结直肠癌患者预后的关系和影响因素[J].药学实践杂志,2016,34(4):366~371 |
| 摘要点击次数: 2017 |
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| 基金项目:上海市卫生局重点项目（20134018） |
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| 中文摘要:目的 探讨树突状细胞-细胞因子诱导的杀伤细胞（dendritic cell-cytokine-induced killers，DC-CIK）治疗与结直肠癌患者预后的关系，以便更好地为临床治疗提供参考。方法 回顾性分析东方肝胆外科医院生物治疗科2012年1月至2014年1月收治的66例结直肠癌患者信息，随访。在以性别、年龄、病理分化程度、TNM分期、接受手术的方式及是否接受靶向治疗为研究基础上，通过Kaplan-Meier单因素和Cox多因素分析，重点探讨DC-CIK治疗对患者预后的影响。结果 Kaplan-Meier单因素分析结果提示：接受DC-CIK治疗在一定程度上能改善患者的预后；Cox多因素分析结果提示：是否接受DC-CIK治疗是影响患者预后的独立因素。结论 接受DC-CIK治疗可改善结直肠癌患者的预后。 |
| 中文关键词:结直肠癌 预后 树突状细胞-细胞因子诱导的杀伤细胞 药物靶向治疗 |
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| The relationship between DC-CIK and colorectal cancer prognoses and its influencing factors |
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| Abstract:Objective To discuss dendritic cell-cytokine-induced killer (DC-CIK) cell therapy effects and clinical outcomes in patients with colorectal cancer in order to have better clinical treatment. Methods A retrospective analysis of the data of 66 patients with colorectal cancer from the Biological Therapy Department of the Eastern Hepatobiliary Surgery Hospital was performed from January 2012 to January 2014, and then was followed up. Taking gender, age, degree of pathological differentiation, TNM staging, surgical methods, and targeted therapy as the research basis, by the Kaplan-Meier single factor and Cox multiple factors analysis we mainly discuss the DC-CIK cell treatment's effect on the prognoses of patients. Results Kaplan-Meier single factor analysis results indicate:to a certain extent, DC-CIK cell therapy can improve the prognoses of patients; Cox multi-factor analysis results indicate whether accepting DC-CIK cell therapy is an independent factor influencing the prognoses of patients. Conclusion DC-CIK cells therapy can improve the prognoses of patients with colorectal cancer. |
| keywords:colorectal cancer prognosis dendritic cell-cytokine-induced killers (DC-CIK) drug targeting therapy |
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