| 紫杉醇自微乳滴丸的制备及体外释放考察 |
| 投稿时间：2015-08-27 修订日期：2016-01-08 点此下载全文 |
| 引用本文：王可兴,秦翠英,韩静,李荣丽,陈仁财.紫杉醇自微乳滴丸的制备及体外释放考察[J].药学实践杂志,2016,34(4):330~333 |
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| 基金项目:国家基础科学人才培养基金资助项目（J1103606） |
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| 中文摘要:目的 研究紫杉醇自微乳滴丸的最佳制备工艺，考察其体外累积释药量。方法 以自微乳与基质的比例、滴距、滴制温度、滴速为考察因素，采用正交试验法，以丸重差异、硬度、圆整度为指标，优选紫杉醇自微乳滴丸的最佳制备工艺，并进行体外累积释药的测定。结果 优选的紫杉醇自微乳滴丸的最佳制备工艺：自微乳与基质配比为1：3，滴距15 cm，滴制温度80℃，滴速30滴/min。结论 优选的工艺稳定、可行，制备的紫杉醇自微乳滴丸溶出度高。 |
| 中文关键词:紫杉醇 自微乳 滴丸 正交试验 体外释放度 |
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| The preparation of self-microemulsifying dropping pills of paclitaxel and its drug release in vitro |
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| Abstract:Objective The research is about optimization of preparation procedure of self-microemulsifying dropping pills of paclitaxel (PTX-SM-DP). The drug release in vitro of PTX-SM-DP was investigated. Methods The ratio of SMEDDS and bases, dropping distance, temperature and speed of dripping were investigated by using the orthogonal test. The weight difference of dropping pill, hardness and roundness were evaluated to optimize the preparation conditions of PTX-SM-DP. Dissolution of vitro was determined. Results The optimal preparation conditions were as follows:the ratio of SMEDDS and bases was 1:3, dropping distance was 15 cm, temperature of dripping preparation was 80℃ and dripping speed was 30 drops/min. Conclusion The optimized technical condition is stable and feasible. PTX-SM-DP can improve paclitaxel dissolution. |
| keywords:paclitaxel self-microemulsifying dropping pills orthogonal test cumulative release |
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