| 二至丸及其组成药味保肝药理作用研究进展 |
| 投稿时间：2015-08-28 修订日期：2015-10-19 点此下载全文 |
| 引用本文：胡冬梅,陈小玲,陆杨,房敏峰,王婧雯,文爱东.二至丸及其组成药味保肝药理作用研究进展[J].药学实践杂志,2016,34(4):289~291,296 |
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| 基金项目:国家自然科学基金资助项目（81302627） |
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| 中文摘要:二至丸由女贞子和墨旱莲两味中药组成，这两味药及其组方均有不同程度的保肝作用。二至丸中含有多种保肝有效成分，主要有三萜类、环烯醚萜类、苯乙醇-苷类、香豆素醚类等，它们能对抗多种化学性肝损伤、抗缺血再灌注性肝损伤以及抗肝纤维化等，其保肝作用机制包括抗氧化应激、抗炎、抑制肝星状细胞增殖和活化、促进肝星状细胞凋亡以及影响肝细胞代谢过程等。总结二至丸及其组成药味女贞子和墨旱莲的保肝作用，探讨其保肝作用机制，以期为进一步研究二至丸药效物质基础提供参考。 |
| 中文关键词:二至丸 女贞子 墨旱莲 肝损伤 保肝作用 |
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| Research progress on hepatoprotective effects of Erzhiwan and its components |
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| Abstract:Erzhiwan includes two components of Chinese herbal medicines-Ligustri Lucidi Fructus and Herba Ecliptae. Ligustri Lucidi Fructus, Herba Ecliptae and their formulation have various hepatoprotective effects. There are many active ingredients in the formulation, such as triterpenes, iridoids, phenethyl alcohol-glucosides, coumarin ethers, etc. They can resist various chemistry-induced hepatic injury, ischemia reperfusion induced hepatic injury, and hepatic fibrosis. The mechanisms of hepatoprotective effect include anti-oxidative stress, anti-inflammatory, inhibition of hyperplasia and activation of liver stellate cell, motivating the apoptosis of liver stellate cell, influencing the metabolic processes of liver cell, ect. We reviewed and summarized the hepatoprotective effects of Erzhiwan and its components Ligustri Lucidi Fructus and Herba Ecliptae and explore the mechanisms of hepatoprotective effect in order to provide information for further research of pharmacodynamic material base. |
| keywords:Erzhiwan Ligustri Lucidi Fructus Herba Ecliptae hepatic injury hepatoprotective effect |
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