| 复方醋酸氯己定软膏质量标准研究 |
| 投稿时间：2014-10-25 修订日期：2015-03-18 点此下载全文 |
| 引用本文：胡文军,邓朝晖,李爱红,慈薇.复方醋酸氯己定软膏质量标准研究[J].药学实践杂志,2016,34(3):258~260,266 |
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| 基金项目:军队医疗机构制剂标准提高科研专项课题(13ZJZ19-3) |
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| 中文摘要:目的 提高复方醋酸氯己定软膏的质量控制标准。方法 增补处方中薄荷脑、樟脑的薄层色谱(TLC)法鉴别;建立高效液相色谱法同时测定处方中醋酸氯已定、盐酸丁卡因含量的方法。结果 薄荷脑、樟脑薄层色谱斑点清晰,可用于鉴别;醋酸氯己定在10.01~160.14 μg/ml范围内线性关系良好,平均回收率为101.5%,RSD为1.8%;盐酸丁卡因在10.01~160.14 μg/ml范围内线性关系良好,平均回收率为100.5%,RSD为2.8%。结论 提高后的质量标准可行。 |
| 中文关键词:复方醋酸氯己定软膏 薄层色谱法 高效液相色谱法 |
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| Quality of control of compound chlorhexidine acetate ointment |
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| Abstract:Objective To improve the standard of the quality control of compound chlorhexidine acetate ointment. Methods TLC was used to control the quality of menthol crystal and camphor. A method to determine chlorhexidine acetate and cocaine hydrochloride simultaneously by HPLC was established. Results The spots of menthol crystal and camphor in TLC were clear. Chlorhexidine acetate and cocaine hydrochloride showed excellent linearity, which were at the range of 10.01-160.14 μg/ml and 10.01-160.14 μg/ml, respectively. The average recoveries were 101.5% (RSD=1.8%) and 100.5% (RSD=2.8%). Conclusion The methods were simple, sensitive and with good reproducibility and could be used to control the quality of compound chlorhexidine acetate ointment. |
| keywords:compound chlorhexidine acetate ointment TLC HPLC |
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