| 冬凌草甲素的结构修饰研究进展 |
| 投稿时间：2014-07-24 修订日期：2014-12-09 点此下载全文 |
| 引用本文：刘洪川,金永生,陈海生.冬凌草甲素的结构修饰研究进展[J].药学实践杂志,2016,34(2):114~115,134 |
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| 基金项目:国家自然基金资助项目(No.21272269) |
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| 中文摘要:冬凌草甲素为贝壳杉烯型二萜类化合物,具有良好的体外抗肿瘤活性,虽然体外活性强,但由于水溶性差、生物利用度低、口服难以吸收等缺点,极大地限制了其临床应用。为了寻找具有更高活性和更好生物利用度的化合物,以开发新的抗肿瘤药物,综述研究者对冬凌草甲素进行的结构改造和修饰的进展。 |
| 中文关键词:冬凌草甲素 唇形科 结构修饰 二萜 |
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| Research progress of structural modification of oridonin |
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| Abstract:Oridonin is an en-kaurene diterpenoids compound which was found to have effect on tumor in vitro. But the clinical application has been limited because of poor water solubility, low bioavailability and oral absorption. Many scholars conducted a large number of structure modification researches of oridonin to search for new diterpenes with higher bio-activities and better bio-availabilities, and to develop new antitumor drugs. In this paper, studies on this aspect of oridonin were reviewed. |
| keywords:oridonin Labtea structure modification diterpene |
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