| 祛斑口服液的质量标准研究 |
| 投稿时间：2014-11-30 修订日期：2015-03-17 点此下载全文 |
| 引用本文：乐佳美,熊筱娟,张凤,朴淑娟,陆文铨.祛斑口服液的质量标准研究[J].药学实践杂志,2016,34(1):66~71 |
| 摘要点击次数: 1433 |
| 全文下载次数: 96 |
|
| 基金项目:军队医疗机构制剂标准提高计划(14ZJZ02-4) |
|
| 中文摘要:目的 建立祛斑口服液的质量标准。 方法 采用薄层色谱法(TLC)对处方中的党参、黄芪、赤芍、白芍、白术、当归进行定性鉴别;采用反相高效液相色谱法(RP-HPLC)对处方中赤芍和白芍中的芍药苷进行含量测定。 结果 定性鉴别方法分离良好、斑点清晰、专属性强。芍药苷检测浓度在18.20~2 330.00 μg/ml范围内与峰面积积分值呈良好的线性关系(r=0.999 9),平均回收率为99.72%,RSD为1.25%。 结论 本方法可对祛斑口服液的主要药味进行准确的定性和定量测定,有效地控制祛斑口服液的质量。 |
| 中文关键词:祛斑口服液 质量标准 薄层色谱法 反相高效液相色谱法 芍药苷 |
| |
| Study on quality standard of Quban oral liquid |
|
|
| Abstract:Objective To establish the quality standard for Quban oral liquid. Method Thin layer chromatography(TLC)was used for quality identification of Codonopsis pilosula, Astragalus membranaceus, Paeonia veitchii, Paeonia lactiflora, Atractylodes macrocephala and Angelica sinensis. The paeoniflorin was determined by RP-HPLC. Result Clear spots were obtained with good separation in TLC identification which was highly specific. The paeoniflorin area and content showed a good linear relationship at the range of 18.20-2 330.00 μg/ml (r=0.999 9). The average recovery was 99.72% (RSD=1.25%). Conclusion This method is simple, rapid, accurate, and which can be used for the quality control of Quban oral liquid. |
| keywords:Quban oral liquid quality standard TLC RP-HPLC paeoniflorin |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
| 关闭 |
|
|
|
