| 鹅掌柴叶挥发油的成分分析及抗炎镇痛活性 |
| 投稿时间：2015-01-14 修订日期：2015-06-16 点此下载全文 |
| 引用本文：庞素秋,金孝勤,孙爱静,王国权,许瑞安.鹅掌柴叶挥发油的成分分析及抗炎镇痛活性[J].药学实践杂志,2016,34(1):56~58,78 |
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| 基金项目:福建省科技重点项目(2012Y0049) |
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| 中文摘要:目的 探讨鹅掌柴新鲜叶挥发油的化学成分及其抗炎镇痛作用。 方法 采用水蒸气蒸馏法得到鹅掌柴叶挥发油(SOLEO),用气相色谱-质谱联用技术(GC-MS)进行SOLEO成分的定性定量分析,并用醋酸扭体法、二甲苯致小鼠耳郭肿胀法两种模型评价SOLEO的抗炎镇痛活性。 结果 GC-MS法测出SOLEO中55个组分,其中组分1~16共占84.28%,为SOLEO的主要成分。4-萜品醇、(-)-斯巴醇、氧化石竹烯、芳樟醇4种成分占总含量的51.86%。SOLEO可明显减少醋酸所致小鼠的扭体次数,可明显缓解二甲苯所致小鼠的耳郭肿胀程度,SOLEO经灌胃给药10 g生药/(kg.d)剂量组的抑制率分别为52.5 %和59.6 %。 结论 SOLEO为鹅掌柴抗炎镇痛药理作用的活性成分之一,为民间以鹅掌柴新鲜叶入药提供科学依据。 |
| 中文关键词:鹅掌柴 挥发油 气相色谱-质谱联用技术 抗炎镇痛活性 |
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| Constituent analysis, analgesic and anti-inflammatory activities of leaves essential oil of Schefflera octophylla |
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| Abstract:Objective To investigate the constituents and analgesic and anti-inflammatory effects of leaves essential oil in Schefflera octophylla. Methods SOLEO was dilated by water vapor. The mouse acetic acid-induced twisting test and mouse auricle swelling test induced by xylene were employed to evaluate the anti-inflammation and analgesia effects of SOLEO. Results 55 constituents of SOLEO were identified by GC-MS. The major constituents, 4-terpenol, (-)-spthulenol,caryophllene oxide and β-linalool with total percent of 51.86% were found. The twisting number and relieve swollen auricle of mice induced by xylene were significantly reduced by SOLEO. Conclusion SOLEO was the major active components of anti-inflammation and analgesia. |
| keywords:Schefflera octophylla essential oil GC-MS anti-inflammation and analgesic activity |
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