| 蛇毒毒素的抗肿瘤作用及其在医药领域的应用 |
| 投稿时间：2013-09-01 修订日期：2014-03-31 点此下载全文 |
| 引用本文：金夕琳,张洁,江海龙,陆一鸣.蛇毒毒素的抗肿瘤作用及其在医药领域的应用[J].药学实践杂志,2015,33(6):502~504,517 |
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| 基金项目:国家自然科学基金项目(No.81274162,30500093);国家科技部“重大新药创制”专项(No.2009ZX09103-690);上海市科委重点项目(No.04JC14002);军队“十一五”计划(No.06Q042);上海市高校优秀青年教师科研专项基金(No.ejd09011) |
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| 中文摘要:目的 探讨蛇毒毒素的抗肿瘤作用及其在医药领域的应用。方法 综述蛇毒毒素的抗肿瘤组分、抗肿瘤作用及其机制的研究进展。结果 蛇毒毒素对多种肿瘤均有抑制作用,具有直接杀伤肿瘤细胞、诱导肿瘤细胞凋亡、抑制血管再生等作用。结论 对蛇毒毒素抗肿瘤组分及其作用机制进行深入研究,是当前抗肿瘤药物研究的重要方向。 |
| 中文关键词:蛇毒毒素 抗肿瘤 |
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| The antitumor effect of snake venom toxins and its application in medical field |
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| Abstract:Objective To discuss the antitumor effect of snake venom toxins and its application in medical field. Methods To review the research progress of composition, the antitumor effect and mechanism of snake venom toxins. Results It was demonstrated that the snake venom toxins can stop various tumor cells from growing, and have the functions of killing the tumor cells, inducing cell death, and inhibition of angiogenesis. Conclusion It is an important direction in antitumor drug research and development to deeply research the composition and the mechanisms of action of the snake venom toxins. |
| keywords:snake venom toxins antitumor |
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