| 温控型胰岛素液体肛门栓药剂学研究 |
| 投稿时间：2014-05-21 修订日期：2015-03-20 点此下载全文 |
| 引用本文：刘丹,赵文萃,肖秋生,王艳萍,张琦,杨文慧.温控型胰岛素液体肛门栓药剂学研究[J].药学实践杂志,2015,33(5):423~425 |
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| 中文摘要:目的 温控型胰岛素液体肛门栓药剂学性质的研究。 方法 采用正交试验法,以形成凝胶时间、胶凝强度、生物黏附力、黏度、胶凝温度作为评价指标,对处方中的泊洛沙姆407和泊洛沙姆188的比例、壳聚糖质量分数和pH值3个因素进行考察,确定最优处方工艺;测定最优处方液体栓剂的胶凝强度、生物黏附力、黏度、胶凝温度。 结果 泊洛沙姆407:泊洛沙姆188(15:25),壳聚糖质量分数0.4%,pH值为5±0.2。 结论 经验证结果良好,液体栓剂强度及生物黏附力良好。 |
| 中文关键词:胰岛素 正交试验 液体栓 |
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| Pharmaceutical studies on thermos sensitive insulin anal liquid suppository |
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| Abstract:Objective To study the pharmaceutical quality of the thermos sensitive insulin anal liquid suppository. Methods Orthogonal test method was used, the forming of a gelatum time, gel strength, bio-adhesive force, viscosity, gelation temperature were taken as the evaluation index, the prescription of poloxamer 407 and poloxamer 188, the proportion of chitosan and pH were investigated, in order to determine the best optimized prescription and measure what was the best choice of the gel strength, biological adhesion force, suppository viscosity, gelation temperature for the final prescription of liquid suppository. Result The best combination of the prescription were 15% of poloxamer 407,25% of poloxamer 188 and 0.4% of chitosan with the pH of 5±0.2. Conclusion The test proved to be equitable with the good intensity and bio-adhesive force of the liquid suppository. |
| keywords:insulin orthogonal test liquid suppository |
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