| 群体药动学应用于个体化给药的研究进展 |
| 投稿时间：2014-07-18 修订日期：2015-03-14 点此下载全文 |
| 引用本文：林艳.群体药动学应用于个体化给药的研究进展[J].药学实践杂志,2015,33(4):293~297,346 |
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| 中文摘要:群体药动学运用经典的药动学原理结合统计学方法,以稀疏数据预测患者血药浓度,可达到监测药物体内过程和指导临床个性化给药的目的。查阅近年来的相关文献,结合实例综述群体药动学应用于治疗窗窄的药物、个体差异大的药物、联合用药、特殊人群用药等方面的最新进展,为其深入研究和指导临床用药提供参考。 |
| 中文关键词:群体药动学 个体化给药 非线性混合效应模型 Bayesian反馈法 |
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| Research progress of population pharmacokinetics applying to individualized medication |
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| Abstract:Combining the classic pharmacokinetic principles and statistical methods, population pharmacokinetics (PPK) can predict individual pharmacokinetic parameters accurately with sparse data in patients, which may be used for monitoring drug concentration in patients and realizing individual dose regimen. In this article, we review the recent application of PPK in drugs with narrow therapeutic windows or great individual differences, combining medication, medication in special populations and so on, providing useful information for further investigation of PPK and its application in clinical medication. |
| keywords:population pharmacokinetics individual dose regimen nonlinear mixed effect model Bayesian forecasting |
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