| 异甘草酸镁预防奥沙利铂肝损伤的临床观察 |
| 投稿时间：2013-12-10 修订日期：2014-03-17 点此下载全文 |
| 引用本文：吕建峰,刘华,叶爱琴,刘君,丁荣杰.异甘草酸镁预防奥沙利铂肝损伤的临床观察[J].药学实践杂志,2015,33(2):171~172 |
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| 中文摘要:目的 观察异甘草酸镁预防奥沙利铂致肝损伤的疗效。 方法 对照组采用奥沙利铂、亚叶酸钙、氟尿嘧啶方案化疗,治疗组采用奥沙利铂、亚叶酸钙、氟尿嘧啶方案化疗同时使用异甘草酸镁,以28 d为1个疗程,治疗周期为2~4个疗程,观察患者发生肝损伤的比例。 结果 对照组肝损伤发生率为44.4%,治疗组肝损伤发生率为19.4%,两组间有显著性差异(P<0.01)。 结论 异甘草酸镁可有效预防奥沙利铂所致的肝损伤,值得临床推广使用。 |
| 中文关键词:奥沙利铂 异甘草酸镁 肝损伤 |
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| Observation of glutathione to prevent oxaliplatin-induced hepatic lesion |
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| Abstract:Objective To observe the curative effect of magnesium isoglycyrrhizinate in prevention of liver injury induced by oxaliplatin. Methods The control group used oxaliplatin, leucovorin, 5-fluorouracil chemotherapy, the treatment group were treated with oxaliplatin, leucovorin, 5-fluorouracil chemotherapy and simultaneous magnesium isoglycyrrhizinate were used at the same time. With 28 d for 1 course of treatment, the treatment period consisted of 2-4 courses, observation of patients and the proportion of liver injury were made. Results In the control group, liver injury incidence rate was 44.4%, the rate of injury was 19.4% in treatment group, there was significant difference between the two groups (P<0.01). Conclusion Magnesium isoglycyrrhizinate could be effective in prevention of oxaliplatin induced liver injury. |
| keywords:oxalic acid platinum magnesium isoglycyrrhizinate injection liver function damage |
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