| 注射用硝普钠在2种溶媒中的稳定性考察 |
| 投稿时间：2013-11-09 修订日期：2014-03-05 点此下载全文 |
| 引用本文：林小明,韦宝含,曾毅,韦平原,梁汉钦,谢伟乾,陈明忠.注射用硝普钠在2种溶媒中的稳定性考察[J].药学实践杂志,2015,33(1):63~64,93 |
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| 基金项目:广西贵港市科技攻关(201305) |
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| 中文摘要:目的 考察注射用硝普钠与5%葡萄糖注射液、0.9%氯化钠注射液配伍的稳定性,为临床合理用药提供依据。方法 采用高效液相色谱法,测定注射用硝普钠分别与2种溶媒(5%葡萄糖注射液、氯化钠注射液)配伍26 h内的含量变化,按2010年版《中国药典》微粒检测法中的光阻法检查微粒,并考察其外观、紫外-可见吸收光谱及pH值和渗透压。结果 26 h内配伍液的外观、紫外-可见吸收光谱、pH值、含量及不溶性微粒均无显著性变化。结论 注射用硝普钠与5%葡萄糖注射液、0.9%氯化钠注射液配伍26 h内稳定。 |
| 中文关键词:硝普钠 高效液相色谱法 配伍 稳定性 |
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| Stability of sodium nitroprusside for injection in two different dissolvants |
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| Abstract:Objective To study the stability of sodium nitroprusside for injection in 5% glucose injection and 0.9% sodium chloride injection,and provide reference for clinical rational drug use. Methods The content of sodium nitroprusside for injection in different dissolvants(5% glueose,sodium chloride injection) within 26 h was determined by HPLC.The change of micro particle was measured by light blockage method in accordance with China pharmacopeia(2010 edition),and the appearance and UV visible absorption spectroscopy and pH, the osmotic pressure of the mixtures were observed as well. Results The changes in appearnace,UV visible absorption spectroscopy,pH value,content and microparticle were not significant. Conclusion Sodium nitroprusside for injection were stable within 26 h after mixing with different dissolvants (5%glueose,sodium chloride injection). |
| keywords:sodium nitroprusside HPLC combination stability |
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