| 生物活性肽-单核细胞迁移抑制因子研究进展 |
| 投稿时间：2013-11-12 修订日期：2014-04-21 点此下载全文 |
| 引用本文：程浩,芮耀诚,章越凡,李铁军.生物活性肽-单核细胞迁移抑制因子研究进展[J].药学实践杂志,2015,33(1):17~19,27 |
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| 基金项目:国家科技重大专项项目:防治心肌缺血的抗炎短肽候选化合物研究(2013ZX09103001-005) |
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| 中文摘要:单核细胞迁移抑制因子(monocyte locomotion inhibitory factor,MLIF)是阿米巴原虫产生的具有抗炎作用的五肽。体内、外研究发现,MLIF可以发挥抗炎和免疫保护作用,对类风湿关节炎、神经损伤、心肌缺血、脑缺血及痴呆具有良好的保护作用。研究证明MLIF通过NF-κB 和MAPK信号通路调节炎症反应和免疫保护。笔者对MLIF的来源和生物活性做一综述。 |
| 中文关键词:单核细胞迁移抑制因子 炎症 免疫 生物活性肽 |
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| Research progress of bioactive peptide monocyte locomotion inhibitory factor |
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| Abstract:Monocyte locomotion inhibitory factor(MLIF)was an anti-inflammatory pentapeptide produced by Entamoeba histolytica.In vivo and in vitro study showed that MLIF displayed anti-inflammatory and immune protection effects and MLIF had protective effects on rheumatoid arthritis,nerve injury,myocardial ischemia,cerebral ischemia and Alzheimer's disease.Studies had shown that MLIF regulated inflammatory response and immune protection through NF-κB and MAPK signal pathways.The sources and biological activities of MLIF were reviewed in this paper. |
| keywords:monocyte locomotion inhibitory factor inflammation immune bioactive peptide |
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