| 脑缺血和再灌注损伤与防治机制的研究进展 |
| 投稿时间：2013-06-07 修订日期：2013-12-20 点此下载全文 |
| 引用本文：吴金华,马慧萍,蒙萍,贾正平.脑缺血和再灌注损伤与防治机制的研究进展[J].药学实践杂志,2014,32(6):401~404,447 |
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| 基金项目:国家科技部重大专项资助项目(2008ZXJ09014-010);甘肃省省自然科学研究基金计划项目(1107RJZA100);全军医药卫生科研基金课题(CLZ11JA06). |
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| 中文摘要:总结脑缺血和再灌注损伤的发生和防治机制的研究进展,展望未来研究趋势。采用文献归纳总结的方法进行分析。脑缺血和再灌注造成的损伤与炎性反应、细胞内Ca2+超载、自由基的迅速增加、兴奋性氨基酸的大量释放等因素有关。防治脑缺血和再灌注损伤的机制主要有缩短缺血时间、阻断谷氨酸受体偶联的Na+和Ca2+内流、清除自由基、抑制凋亡、减轻炎症反应、促进神经元生长与修复等多个方面。多靶点联合治疗可能是防治脑缺血和再灌注损伤的一个方向。 |
| 中文关键词:脑缺血 再灌注损伤 防治 损伤机制 |
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| Mechanisms of damage and treatments of cerebral ischemia and reperfusion |
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| Abstract:To summarize the advances in mechanisms of damage and treatments of cerebral ischemia and reperfusion and forecasts future research directions.The existing achievements in literatures were summarized.Cerebral ischemia and reperfusion damage were related to inflammatory response, intracellular calcium overload, free radicals injury, release of excitatory amino acids and other factors. The treatments included reducing ischemia time, blocking glutamate receptors, free radical scavenging, inhibition of apoptosis, reducing inflammation, and promoting neuronal growth, etc. Multi-target treatment would be future directions in treatment of cerebral ischemia. |
| keywords:cerebral ischemia reperfusion damage prevention and treatment mechanism of damage |
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