| 盐酸曲马多与枸橼酸芬太尼在氯化钠注射液中的稳定性研究 |
| 投稿时间：2013-01-19 修订日期：2013-04-10 点此下载全文 |
| 引用本文：方宝霞,陈富超,李春雷,刘慧敏,朱雪松.盐酸曲马多与枸橼酸芬太尼在氯化钠注射液中的稳定性研究[J].药学实践杂志,2014,32(5):348~351 |
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| 中文摘要:目的 考察盐酸曲马多与枸橼酸芬太尼注射液在0.9%氯化钠注射液中的配伍稳定性。方法 在室温条件下,观察两药配伍后的外观及pH值变化,盐酸曲马多与枸橼酸芬太尼的含量测定采用SinoChrom ODS-BP色谱柱,以乙腈-0.05 mol/L磷酸二氢钾水溶液(25:75)为流动相,流速为1.0 ml/min。结果 配伍液中盐酸曲马多与枸橼酸芬太尼的含量均大于98%,72 h内外观与pH值均未见明显变化。结论 在室温条件下,盐酸曲马多与枸橼酸芬太尼注射液在0.9%氯化钠注射液中72 h内保持稳定。 |
| 中文关键词:曲马多 芬太尼 配伍稳定性 高效液相色谱法 |
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| Stability of tramadol hydrochloride with fentanyl citrate in 0.9% sodium chloride injection |
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| Abstract:Objective To study the stability of tramadol hydrochloride with fentanyl citrate in 0.9% sodium chloride injection.Methods The changes in appearance and pH value of the mixture of the two injections in 0.9% sodium chloride injection within 72 hours at ambient temperature were observed. The concentrations of the two drugs were determined by HPLC. The chromatographic separation was achieved on SinoChrom ODS-BP column, and the mobile phase consisted of acetonitrile:0.05 mol/L potassium dihydrogen phosphate (25:75) at a flow rate of 1.0 ml/min..Results No significant differences were found in the pH value and appearance of the solution. The contents of tramadol hydrochloride and fentanyl citrate were high than 98% within 72 hours.Conclusion The mixture of tramadol hydrochloride with fentanyl citrate in 0.9% sodium chloride injection was stability within 72 hours under room temperature. |
| keywords:tramadol fentanyl compatibility stability HPLC |
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