| 青霉属生物中分离出的抗真菌四肽的固相合成 |
| 投稿时间：2013-04-28 修订日期：2013-10-22 点此下载全文 |
| 引用本文：杨璐晶,王露,李文娟,李仁武,王晓燕,胡宏岗.青霉属生物中分离出的抗真菌四肽的固相合成[J].药学实践杂志,2014,32(5):342~343,378 |
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| 基金项目:国家科技重大专项(2012ZX09502001-005). |
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| 中文摘要:目的 以固相合成法合成抗真菌四肽D-Phe-Val-D-Val-Tyr-OH。方法 采用固相合成法通过4步反应顺利获得目标四肽,所得化合物的结构通过MS、1H NMR等光谱确证。结果 合成得到了抗真菌四肽D-Phe-Val-D-Val-Tyr-OH,总收率为47.0%。结论 合成方法具有可行性,操作简便、总收率高,目标化合物可用于抗真菌药物研究。 |
| 中文关键词:抗真菌 四肽 固相合成 |
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| Solid-phase synthesis of the antifungal tetrapeptide from the culture of penicillium canescens |
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| Abstract:Objective To synthesize the antifungal tetrapetide by solid-phase synthesis method.Methods The solid-phase peptide synthesis was chosen for getting the desired target tetrapeptide and its structure was confirmed by MS and 1H NMR. Results The synthesis of the D-Phe-Val-D-Val-Tyr-OH was realized with yield of 47%.Conclusion The synthetic method was feasible and practical. The desired target tetrapeptide could be used for screening of antifungal activity. |
| keywords:antifungal tetrapeptide solid-phase synthesis |
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