| 维生素D受体基因的多态性与检测方法 |
| 投稿时间：2013-12-20 修订日期：2014-04-26 点此下载全文 |
| 引用本文：游春华,熊筱娟,王清华,陈万生,高守红.维生素D受体基因的多态性与检测方法[J].药学实践杂志,2014,32(5):329~331,392 |
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| 中文摘要:近年研究发现,维生素D缺乏除与骨软化相关外,还与高血压、糖尿病、代谢综合征等多种疾病相关。维生素D在体内经肝脏和肾脏两次羟基化后作用于其受体而发挥生理作用。笔者通过查阅国内外相关文献,介绍维生素D与疾病的关系及维生素 D受体基因多态性研究现状,阐述检测维生素D常用方法的优缺点,提出检测维生素D的最佳方法及其受体基因多态性检测的重要性,从而指导临床医生合理用药。 |
| 中文关键词:维生素D 基因多态性 维生素D受体 合理用药 |
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| Study on receptor gene polymorphism and detection method of vitamin D |
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| Abstract:In recent years, many studies have found that vitamin D insufficiency is associated with osteomalacia, hypertension, diabetes, metabolic syndrome and other diseases. Vitamin D must be hydroxylated in the liver by a 25-hydroxylase for the first time, and then in the kidney by a 1α-hydroxylase for the second time to form the active metabolite 1, 25-dihydroxy vitamin D, which binds to the intracellular vitamin D receptor and exerts its effects. This paper reviewed the relationship between vitamin D and disease, present research situation of gene polymorphism of vitamin D receptor, and the advantages and limitations of several methods of vitamin D detection, and proposed the best method for detecting vitamin D receptor gene polymorphism and the importance of the detection state to guide clinicians to use drug rationally. |
| keywords:vitamin D gene polymorphism vitamin D receptor rational drug use |
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