| Lox-1—心血管疾病防治的新靶标 |
| 投稿时间：2013-02-27 修订日期：2013-10-23 点此下载全文 |
| 引用本文：李倩,芮耀诚.Lox-1—心血管疾病防治的新靶标[J].药学实践杂志,2014,32(5):321~323 |
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| 中文摘要:目的 Lox-1(血凝素样氧化低密度脂蛋白受体1),是ox-LDL的主要受体之一,在血管内皮功能障碍、泡沫细胞形成及动脉粥样硬化斑块的稳定性中具有重要作用。方法 为了探讨Lox-1在心血管疾病中的作用,笔者对有关Lox-1在心血管疾病中的研究进展进行回顾性分析。结果 Lox-1作为ox-LDL新型清道夫受体,在心血管疾病的发生发展中具有重要的作用。结论 Lox-1可能为防治心血管疾病的药物研究提供新的思路。 |
| 中文关键词:血凝素样氧化低密度脂蛋白受体1 动脉粥样硬化 氧化低密度脂蛋白 |
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| Lox-1, a new target in cardiovascular disease |
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| Abstract:Objective Lox-1 (lectin-like oxidized low-density lipoprotein receptor-1) was one of the main receptor of ox-LDL, which took an important role in vascular endothelial dysfunction, the formation of foam cells, and the stability of atherosclerotic plaques. To investigate the role of Lox-1 in cardiovascular diseases.Methods The literatures of Lox-1 in cardiovascular diseases retrospectively were reviewed.Results As a new ox-LDL scavenger receptor, Lox-1 played an important role in cardiovascular diseases.Conclusion Lox-1 might provide new ideas for cardiovascular diseases. |
| keywords:lectin-like oxidized low-density-lipoprotein receptor-1 atherosclerosis oxidized low-density lipoprotein |
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