| 口服固体自微乳化给药系统的研究进展 |
| 投稿时间：2013-02-26 修订日期：2013-09-02 点此下载全文 |
| 引用本文：赵佳丽,温许,张晶,刘建清,宋洪涛.口服固体自微乳化给药系统的研究进展[J].药学实践杂志,2014,32(4):257~260 |
| 摘要点击次数: 1342 |
| 全文下载次数: 321 |
|
|
| 中文摘要:目的 对新近发展的固体自微乳化给药系统(S-SMEDDS)文献进行综述。方法 查阅近年国内外相关文献并进行归纳和总结。结果 对固体自微乳的载体、固化技术以及缓控释制剂进行了探讨,为研究水难溶性药物的生物利用度及适合药物释放特性的S-SMEDDS技术提供相关参考。结论 固体自微乳化系统可以显著提高难溶性药物的口服生物利用度,且兼顾了液态自微乳和固体制剂二者的优势,是一个极具潜力的新型制剂。 |
| 中文关键词:固体自微乳化给药系统 固化技术 口服生物利用度 |
| |
| Progress on solid self-microemulsifying drug delivery system for oral administration |
|
|
| Abstract:Objective To review the newly developed solid self-microemulsifying drug delivery system(S-SMEDDS).Methods Relevant literatures at home and abroad in recent years were consulted and summarized.Results Solid self-microemulsions carrier, solidification technology and controlled release formulations were discussed, in order to provide relevant references for improving the bioavailability of water-insoluble drugs and the SMEDDS technology for drug release characteristics.Conclusion The utilization of the solid self-emulsifying drug delivery system could significantly enhance the oral bioavailability of water-insoluble drugs.As a new formulation, S-SMEDDS presented huge potential. |
| keywords:S-SMEDDS solidification technology oral bioavailability |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
| 关闭 |
|
|
|
