| 辐射致组织损伤凋亡机制的研究概况 |
| 投稿时间：2013-03-11 修订日期：2013-06-14 点此下载全文 |
| 引用本文：杨宏,倪敏,赵心彬,陶霞.辐射致组织损伤凋亡机制的研究概况[J].药学实践杂志,2014,32(2):96~97,149 |
| 摘要点击次数: 1199 |
| 全文下载次数: 72 |
|
|
| 中文摘要:辐射能够导致组织损伤,其机制通常与细胞凋亡、坏死、炎症等相关。其中细胞凋亡是辐射损伤的主要特征之一,但是凋亡发生的具体机制仍不清楚。研究表明,有多条通路涉及其中,代表性的通路有:聚ADP核糖聚合酶(PARP)、p53、自由基、神经酰胺、p38通路等。本文围绕上述蛋白质分子,综述了凋亡途径在辐射致组织损伤的作用。 |
| 中文关键词:电离辐射 损伤机制 细胞凋亡 脱氧核糖核酸损伤 神经酰胺 |
| |
| Role of apoptosis in radiation-induced tissue damage |
|
|
| Abstract:Ionizing radiation is able to induce tissue damage, which is related to cell apoptosis, necrosis and inflammation, etc. The signaling pathway underlying radiation-induced apoptosis remains unclear. However, it's well-accepted that several targets were activated in this process, such as poly (ADP-ribose) polymerase, p53, p38, ceramide, free radicals, etc. Based on these targets, the role of apoptosis in radiation-induced tissue damage was elaborated in this review briefly. |
| keywords:ionizing radiation damage mechanism cell apoptosis DNA damage ceramide |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
| 关闭 |
|
|
|
