| 叶酸在心脑血管疾病防治中的机遇与挑战 |
| 投稿时间：2012-12-14 修订日期：2013-04-08 点此下载全文 |
| 引用本文：成彦琼,张浩,王威,顾小飞,刘爱军.叶酸在心脑血管疾病防治中的机遇与挑战[J].药学实践杂志,2013,31(5):330~333,350 |
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| 基金项目:国家自然科学基金资助项目(81273505). |
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| 中文摘要:叶酸缺乏可导致高同型半胱氨酸血症,而高同型半胱氨酸血症是心脑血管疾病的独立危险因素。过去认为补充叶酸可降低体内同型半胱氨酸水平,从而预防心脑血管疾病的发生。但随着大量临床随机对照试验的进行,人们发现降低同型半胱氨酸血症并不能为心血管疾病患者带来益处,脑卒中方面的益处还需要更多临床数据证明。叶酸等B族维生素在心脑血管疾病的预防领域还存在着很大的挑战。笔者就目前叶酸等在心脑血管疾病中的应用现状及存在问题作一综述。 |
| 中文关键词:叶酸 B族维生素 同型半胱氨酸 心血管疾病 脑卒中 |
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| New challenge of folic acid on prevention of cardiovascular and cerebrovascular diseases |
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| Abstract:The lack of folic acid which could cause hyperhomocysteine had revealed an obviously relationship with cardiovascular and cerebrovascular diseases. Plenty of studies had shown that hyperhomocysteine was an independent risk factor of cardiovascular and cerebrovascular diseases. Folic acid supplementation might be an effective method to decrease homocysteine and prevent cardiovascular and cerebrovascular diseases,while some studies question about it. So there was a new challenge of folic acid on prevention of cardiovascular and cerebrovascular diseases. |
| keywords:folic acid B-vitamin homocysteine cardiovascular disease stroke |
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