| 草乌甲素滴丸成型工艺研究 |
| 投稿时间：2012-07-19 修订日期：2012-10-19 点此下载全文 |
| 引用本文：段申富,石军飞.草乌甲素滴丸成型工艺研究[J].药学实践杂志,2013,31(3):217~219 |
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| 中文摘要:目的 确立草乌甲素滴丸的最佳成型工艺。方法 采用正交试验法,以滴丸的丸形、溶散时间以及滴丸的质量差异系数为评价指标,优选药物与基质配比、药液温度、滴速以及滴头的口径,确定最佳滴制条件。结果 原料药与基质以1:6:1.5~1:8:2配比,药液温度为(80±1)℃,滴速为50滴/min,滴口内外径为1.32/2.28 mm的滴头为最佳滴制条件。结论 草乌甲素滴丸滴制方法简单、操作容易切实可行,成品率高,质量稳定。 |
| 中文关键词:草乌甲素滴丸 成型工艺 正交试验 |
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| Study on molding technology of Bulleyaconitine A dropping pill |
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| Abstract:Objective To establish the optimized molding technology of Bulleyaconitine A dropping pills. Methods The optimum extraction process was selected with orthogonal experiment, difference of pill mass, dissolution-time and quality difference coefficient of pill were taken as indicators. Through examination, the ratio of drug to matrix, mixture temperature, dropping speed and the external diameter of burette were selected as the best dropping conditions. Results The best dropping conditions were that the ratio of drug to matrix was 1:6:1.5~1:8:2, the mixture temperature was (80±1)℃, the dropping speed was 50 drops per minute, and the external diameter of burette was 1.32/2.28 mm. Conclusion The molding technology of Bulleyaconitine A dropping pills was a very simple, feasible, stable and high-achievement ratio. |
| keywords:Bulleyaconitine A dropping pills molding technology orthogonal experiment |
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