| 川参通注射液HPLC指纹图谱的研究 |
| 投稿时间：2012-07-03 修订日期：2012-10-09 点此下载全文 |
| 引用本文：赵晶,曹红,邢俊波.川参通注射液HPLC指纹图谱的研究[J].药学实践杂志,2013,31(2):137~139 |
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| 中文摘要:目的 建立川参通注射液的指纹图谱,作为川参通注射液的质量评价指标。方法 采用高效液相色谱法,流动相为乙腈-0.1%甲酸水溶液,梯度洗脱,柱温35℃,流速1.0 ml/min,检测波长281 nm。结果 采用《中药色谱指纹图谱相似度评价系统》(2004A 版)对11批川参通注射液的指纹图进行处理,确定了11个共有峰,11批样品的相似度均大于0.970。结论 该方法简便,稳定,重复性好,可作为川参通注射液的质量评价指标。 |
| 中文关键词:川参通注射液 指纹图谱 高效液相色谱法 |
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| The fingerprint analysis on Chuanshentong injection by HPLC |
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| Abstract:Objective To establish the fingerprint analysis for quality evaluation index of of Chuanshentong injection.Methods The fingerprints were established by HPLC. The mobile phase was acetonitrile-0.1% aqueous Formic acid solution in a gradient elution mode. The column temperature was maintained at 35℃. The flow rate was 1.0 ml /min,and detection wavelength was set at 281 nm.Results 11 common peaks were obtained in the fingerprint of 11 batches of Chuanshentong injection with the help of peaks match with Similarity Evaluation System for Chromatographic Fingerprint of TCM(Version 2004A). The similarity among 11 batches of Chuanshentong Injection was calculated more than 0.970.Principal components analyses was carried out to study the common HPLC fingerprint.Conclusion The method was simple,accurate and sensitive which could be used to evaluate the quality of Chuanshentong injection. |
| keywords:Chuanshentong injection fingerprint HPLC |
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