| 姜黄素在PEG-400中的溶解度及稳定性研究 |
| 投稿时间：2012-06-01 修订日期：2012-10-30 点此下载全文 |
| 引用本文：仝永涛,高勇,高保安,岳力群,陈建明.姜黄素在PEG-400中的溶解度及稳定性研究[J].药学实践杂志,2013,31(1):53~56 |
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| 作者 | 单位 | E-mail | | 仝永涛 | 第二军医大学, 研究生管理大队药学队, 上海 200433 | | | 高勇 | 第二军医大学, 研究生管理大队药学队, 上海 200433 | | | 高保安 | 第二军医大学, 药学院, 上海 200433 | | | 岳力群 | 第二军医大学, 药学院, 上海 200433 | | | 陈建明 | 第二军医大学, 药学院, 上海 200433 | yjcjm@163.com |
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| 中文摘要:目的 研究姜黄素在聚乙二醇-400(PEG-400)中的溶解度和稳定性,并筛选合适的稳定剂提高其灭菌稳定性。方法 通过溶解度测定法测定姜黄素在PEG-400中的溶解度,加速试验考察其在不同pH条件下的稳定性,并筛选合适的稳定剂提高其灭菌稳定性,然后通过恒温加速试验计算推测含有稳定剂的姜黄素PEG-400溶液的有效期。结果 姜黄素在PEG-400中的溶解度为42 mg/ml,最稳定pH值为3.70;0.1%的没食子酸丙酯可以提高姜黄素的PEG-400溶液灭菌稳定性,使灭菌前后的姜黄素含量几乎没有变化;室温(25℃)下,含0.1%没食子酸丙酯的姜黄素PEG-400溶液有效期可达296.1 d,而低温(6℃)时,有效期可以达到5.5年。结论 本研究表明PEG-400可显著提高姜黄素的溶解度,通过加入0.1%的没食子酸丙酯可显著提高姜黄素PEG-400溶液的稳定性,并且该溶液可经高压灭菌。 |
| 中文关键词:姜黄素 聚乙二醇-400 溶解度 高压灭菌 稳定性 |
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| Study on the solubility and stability of curcumin in PEG-400 |
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| Abstract:Objective To study the solubility and stability of curcumin in PEG-400 and screen the best suitable stabilizer to improve the autoclave stability. Methods Solubility determination was used to determine the solubility of curcumin in PEG-400.The stability under different pH conditions was studied by accelerated testing. The best suitable stabilizer was screened to improve the autoclave stability and the validity of the curcumin solution in PEG-400 with stabilizer was speculated by accelerated testing. Results The solubility of curcumin in PEG-400 was 42 mg/mL;the most stable pH was 3.70. The 0.1% propyl gallate could improve the sterilization stability of curcumin in PEG-400. At room temperature (25℃), the validity duration of curcumin PEG-400 solution with 0.1% propyl gallate was 296.1 days and if at low temperature (6℃), it coulb be up to 5.5 years.Conclusion The study showed that the solubility of curcumin was greatly improved and 0.1% propyl gallate could greatly improve the sterilization stability of curcumin in PEG-400. |
| keywords:curcumin PEG-400 solubility autoclaving stability |
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