| 豨莶草总黄酮对大鼠脑缺血损伤的保护作用及其作用机制研究 |
| 投稿时间：2012-05-16 修订日期：2012-10-08 点此下载全文 |
| 引用本文：娄月芬,李盈,胡滨.豨莶草总黄酮对大鼠脑缺血损伤的保护作用及其作用机制研究[J].药学实践杂志,2013,31(1):42~44 |
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| 中文摘要:目的 探讨豨莶草总黄酮对大鼠局灶性脑缺血损伤的影响及其作用机制。方法 将SD大鼠随机分为6组:假手术组、模型组、银杏叶片(50 mg/kg)组及豨莶草总黄酮低、中、高剂量(5、10、20 mg/kg)组。采用线栓法建立大鼠局灶性脑缺血模型。观察豨莶草总黄酮对大鼠神经行为、脑梗死面积和脑组织含水量的影响。测定大鼠脑组织中丙二醛(MDA)含量及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)的活性。结果 豨莶草总黄酮可明显改善大鼠神经功能缺陷,减轻脑水肿,减少脑梗死面积,降低脑组织MDA含量,提高脑组织SOD及GSH-Px的活性。结论 豨莶草总黄酮有抗脑缺血损伤作用,作用机制可能与其抗氧化作用有关。 |
| 中文关键词:豨莶草总黄酮 脑缺血 抗氧化 丙二醛 超氧化物歧化酶 谷胱甘肽过氧化物酶 |
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| Protective effect of total flavonoids in Herba Siegesbeckiae on cerebral ischemia in rats |
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| Abstract:Objective To study the protective effect and possible mechanism of total flavonoids in Herba Siegesbeckiae on focal cerebral ischemia in rats.Methods Sprague Dawley (SD) rats were randomly divided into 6 groups: sham operation group, model group, total flavonoids of Herba Siegesbeckiae groups with low, moderate and high dose (5, 10, 20 mg/kg)and ginkgo leaf tablet group (50 mg/kg). Focal cerebral ischemia model was established by middle cerebral artery occlusion. The effects of Herba Siegesbeckiae total flavonoids on nervous behavior, cerebral infarct volume and the content of brain water were observed in rats. The activities of malondialdehyde (MDA), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) in cerebral tissues were measured. Results total flavonoids of Herba Siegesbeckiae could improve the neurological function, reduce the cerebral infarct volume, the content of brain water and the activity of MDA, increase the activity of SOD and GSH-Px. Conclusion Total flavonoids of Herba Siegesbeckiae could alleviate focal cerebral ischemia injury, and the mechanism might be related to anti-oxidant effect. |
| keywords:Herba Siegesbeckiae total flavonoids cerebral ischemia anti-oxidant MDA SOD GSH-Px |
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