| 百瑞口服液澄清工艺研究 |
| 投稿时间：2011-11-29 修订日期：2012-10-17 点此下载全文 |
| 引用本文：闫俊,宣伟东,卞俊.百瑞口服液澄清工艺研究[J].药学实践杂志,2013,31(1):32~34 |
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| 基金项目:上海市卫生局局级科研课题(2012085号). |
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| 中文摘要:目的 采用II型ZTC1+1天然澄清剂,建立百瑞口服液的澄清工艺。方法 考察澄清剂的加入顺序、加入量、澄清时间对口服液澄明度的影响;采用HPLC法测定口服液中紫云英苷含量,采用紫外分光光度法测定口服液中总黄酮含量。结果 确定了口服液的澄清工艺:以先B组分后A组分的次序加入20%的澄清剂,各组分的澄清时间均为12 h。结论 ZTC1+1天然澄清剂不影响紫云英苷及总黄酮等有效成分的含量,可作为制备百瑞口服液的除杂澄清工艺。 |
| 中文关键词:百蕊草 口服液 ZTC1+1-Ⅱ 澄清工艺 |
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| Study on clarification process of Bairui oral liquid |
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| Abstract:Objective To establish a optimum clarification process of Bairui oral liquid with new ZTCI+1-Ⅱ natural clarifying agents. Methods The effects on clarification of Bairui oral liquid were evaluated based on the factors such as adding sequence, added amount and clarification time of ZTCl+1-Ⅱ clarifiers A and B. The contents of astragalin and total flavones were determinate by the HPLC and UV methods respectively to evaluate the removing activities of ZTCl+1-Ⅱon active components. Results The selected clarification process conditions were: adding 20% percentage of each components of ZTCl+1-Ⅱto the condensed herb extract solution, the adding sequence was clarifiers B before clarifiers A, and the clarification time was 12 h, respectively. Conclusion The contents of astragalin and total flavones were not decreased by clarification process, ZTCl+1-Ⅱ could be used as the removing impurity of Bairui oral liquid. |
| keywords:Thesium chinensis Turcz oral liquid ZTCI+1-Ⅱ clarification process |
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