| 藤甲酰苷缓释片的制备及体外释药因素考察 |
| 投稿时间：2012-02-06 修订日期：2012-05-22 点此下载全文 |
| 引用本文：陈烨,王洋,刘忠忱,李文君,邓晶晶,徐利锋.藤甲酰苷缓释片的制备及体外释药因素考察[J].药学实践杂志,2012,30(5):369~371,375 |
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| 基金项目:国家"十一五"规划"重大新药创制"重大科技专项资助项目(2009ZX09103-030);辽宁大学"211工程"三期建设重点资助项目 |
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| 中文摘要:目的 制备藤甲酰苷缓释片并研究其体外药物释放行为。方法 通过亲水凝胶骨架型缓释技术,以羟丙基甲基纤维素(HPMC)为缓释材料、乙基纤维素(EC)为凝胶骨架材料制备藤甲酰苷缓释片;考查了释放介质的 pH 值、骨架材料与其用量、致孔剂的类型与用量、压片压力等工艺因素和条件对藤甲酰苷缓释片体外药物释放行为的影响。结果 药物的释药速率受骨架材料的规格和用量、致孔剂种类的影响;释放介质 pH 值、转速和压片压力对释药速率有一定影响。结论 研制的藤甲酰苷缓释片处方合理,有较好的可控性和重现性。 |
| 中文关键词:藤甲酰苷 缓释片 体外释放 羟丙基甲基纤维素 |
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| Preparation and in vitro release of Garcinia glycosides sustained-release tablets |
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| Abstract:Objective To prepare Garcinia glycosides sustained-release tables and study their in vitro release characteristics. Methods Garcinia glycosides sustained-release tablets were prepared by hydroxypropylmethyl cellulose (HPMC) as gel matrix material and ethyl cellulose (EC) as skeleton material. Factors influencing the release rate of Garcinia glycosides from the sustained-release tablets, such as pH of release medium, skeleton material and amount of HPMC, porogen of type and amount, and tabletting pressure, were studied. Results Garcinia glycosides release rate was controlled obviously by the specifications and amount of skeleton material and porogen type. While the influence of pH, speed and tabletting pressure had certain influences to the release rate. Conclusion The selected formulation of Garcinia glycosides sustained-release tablets was reasonable with good controllability and reproducibility. |
| keywords:Garcinia glycosides sustained-release tablets in vitro release HPMC |
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