| 固体脂质纳米粒制备及应用研究进展 |
| 投稿时间：2011-10-25 修订日期：2011-12-23 点此下载全文 |
| 引用本文：夏爱晓,宋倩倩,孙渊.固体脂质纳米粒制备及应用研究进展[J].药学实践杂志,2012,30(5):331~333,368 |
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| 中文摘要:目的 综述固体脂质纳米粒制备及应用进展。方法 以国内外有代表性的文献和资料为依据,将固体脂质纳米粒的制备及应用等情况进行了分析与归纳。结果 固体脂质纳米粒的多种制备方法各有优、缺点,其中以高压乳匀法和微乳法被推崇。调整制备参数可调整药物的包封率和释药曲线。结论 固体脂质纳米粒是一种性能优异、有发展前景的新型给药系统。 |
| 中文关键词:固体脂质纳米粒 理化性质 制备工艺 应用 |
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| Preparation and application of solid lipid nano-particles |
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| Abstract:Objective To review the latest research progress of the solid lipid nano-particle. Methods Domestic and foreign representative literature information of solid lipid nano-particles and its application were analyzed and summarized. Results Many kinds of preparation methods of solid lipid nano-particle had advantages and disadvantages, the high pressure homogenization technique and micro-emulsion method were recommended. Adjusting preparation parameters could be adjusted drug encapsulation efficiency and drug delivering curve. Conclusion Solid lipid nano-particle was a kind of excellent performance, which could be promising new drug delivery system. |
| keywords:solid lipid nano-particles physicochemical properties preparation technology application |
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