| 炎痛平透皮软膏的制备及活血作用的探讨 |
| 投稿时间：2011-12-08 修订日期：2012-03-31 点此下载全文 |
| 引用本文：何爱明,徐洁,王艺辉,林世明.炎痛平透皮软膏的制备及活血作用的探讨[J].药学实践杂志,2012,30(4):269~274,278 |
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| 中文摘要:目的 通过正交试验筛选出最佳配方及工艺,制备炎痛平透皮软膏剂,探讨其活血作用.方法 以60 min体外累积透皮速率为指标,采用四因素三水平L9(34)正交试验,通过研和法筛选出最佳配方及工艺,并对其进行质量评定.将小鼠分为空白对照组与模型组,各组再分为6组,每组各6只,组别分别为:凡士林组,凡士林+脂肪醇组,小、中、大剂量炎痛平组和双氯芬酸二乙胺(扶他林)组.用微循环障碍法与显微测微法,在不同时间测量各组动物造模前与造模后的微动、静脉管径的差值(△A、△V), |
| 中文关键词:炎痛平透皮软膏剂 正交试验 活血作用 |
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| Preparation and promoting blood circulation effect of Yantongping transdermal ointments |
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| Abstract:Objective To find out the best prescription method for Yantongping transdermal ointments through orthogonal design and research on the effect of promoting blood circulation. Methods With 60 minutes in vitro cumulative penetration rate, using L9(34) orthogonal experiment,the best formula and technology were found out through grinding method,and quality thereafter was evaluated. Mice was picked up as blank groups and model groups, each respectively was divided into six smaller groups as Vaseline, Vaseline and Fatty Alcohol.Yantongping transdermal ointments (low dosage),Yantongping transdermal ointments (medium dosage),Yantongping transdermal ointments (high dosage) and Voltaren Emulsions.△A and △V were measured before and after modeling by microcirculation method and microscopic micro-distance measuring method,while the blood circulation function of each medicine by the scoring of the blood of veinule was compared.Results The bestprescription was confirmed by A2B2C3D2.that was with the weight of the traditional Chinese drugs (TCD) Vaseline ratioes (A) to 50%,with the weight of TCD and Fatty Alcohol ratios (B) to 25%,the order of reagent was as follow:Fatty Alcohol,TCD,Vaseline.The grinding temperature was 80℃,and it passed five quality evaluation asphysical appearance,melting point,water value,stability,irritation.Before modeling,in the △A level measured,antongping group (low dosage) had statistical significance over Vaseline and Fatty Alcohol group in 30 min (P<0.05),while Yantongping group (medium dosage and high dosage) had obviously statistical significance over Vaseline and Fatty Alcohol group in different time periodsin the △A and△V level (P<0.01).In the blood flow quality evaluation measured,Yantongping group (low dosage) had statistical significance over Vaseline and Fatty Alcohol group in 20 min,30 min (P<0. 05); while Yantongping group (medium and high dosage) had obviously significant statistical significance over Vaseline and Fatty Alcohol group (P <0.01).After modeling, in the△A level, Yantongping group (low dosage) had statistical significance over Vaselineand and Fatty Alcohol group in 20 min ( P<0. 05);Yantongping group (low dosage) in 30 min, Yantongping group (medium and high dosage) had obviously significent statistical significance over Vaseline and Fatty Alcohol group in the△A and△V level. In the blood flow quality evaluation measured,Yantongping group (low,medium and high dosage) had obviously significant statistical significance over Vaseline and Fatty Alcohol group (P<0. 01).Conclusions Yantongping transdermal ointments prepared by the best prescription had a good function of promoting blood circulation. |
| keywords:Yantongping transdermal ointments orthogonal design promoting blood circulation |
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