| 西罗莫司纳米结构脂质载体分散液的制备及其体外释放度考察 |
| 投稿时间：2012-02-14 修订日期：2012-03-23 点此下载全文 |
| 引用本文：吴昊,宋洪涛.西罗莫司纳米结构脂质载体分散液的制备及其体外释放度考察[J].药学实践杂志,2012,30(3):189~193 |
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| 基金项目:福建省自然科学基金(2010J01218). |
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| 中文摘要:目的 优化西罗莫司纳米结构脂质载体(sirolimus nanostructured lipid carriers,SRL-NLC)分散液的处方,并考察其体外释放度。 方法 采用星点设计-效应面法(central composite design-response surface methodology,CCD-RSM)优化SRL-NLC分散液的处方,并以粒径、分布系数、载药量和包封率作为评价指标,采用正相透析袋法考察SRL-NLC分散液在0.4%SDS(十二烷基硫酸钠)溶液中的释放度。 结果 经优化的S |
| 中文关键词:纳米结构脂质载体 制备 表征 正相透析袋法 体外释放 |
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| Preparation and in vitro releasing of sirolimus-nanostructured lipid carriers dispension |
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| Abstract:Objective To optimize the preparation and study in vitro releasing of SRL-NLC dispersion. Methods Central composite design-response surface methodology was used to optimize dispersion formulation,then in vitro releasing in 0.4% SDS(sodium lauryl sulfate) solution was explored by normal phase dialysis bag method. Results The optimal dispersion had PS(particle size):82.54nm,PI(polydisperity index):0.207, Zeta potential: -18.0 mv,DL (drug-loading): 1.829%, and EE(entrapment efficiency): 91.3%; SRL-NLC dispersion had a characterization of 60.1% accumulated releasing in 0.4%SDS solution. Conclusion The optimal formulation had good feasibility and reproducibility, in vitro releasing curve showed SRL-NLC dispersion had a characterization of 60.1% accumulated releasing in 0.4% SDS solution. |
| keywords:NLC preparation characterization normal phase dialysis bag method in vitro releasing |
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