| 1-丁基-3-甲基咪唑-L-樟脑磺酸盐催化合成monastrol |
| 投稿时间：2010-12-22 修订日期：2011-05-23 点此下载全文 |
| 引用本文：袁文琳,夏天一,沈颂章,王小燕,何邦平,孙青龑.1-丁基-3-甲基咪唑-L-樟脑磺酸盐催化合成monastrol[J].药学实践杂志,2011,29(6):455~456,459 |
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| 基金项目:中国人民解放军总参谋部实验室建设与管理研究项目(SYSXZZ110501),第二军医大学大学生创新能力培养计划面上项目(MS2010043),第二军医大学大学生创新能力培养计划重点项目(ZD2009001). |
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| 中文摘要:目的 探索环境友好、操作简便的monastrol合成方法。 方法 以间羟基苯甲醛、乙酰乙酸乙酯和硫脲为起始原料,在无溶剂微波加热条件下,用绿色室温离子液体1-丁基-3-甲基咪唑-L-樟脑磺酸盐催化Biginelli反应合成monastrol。 结果 1-丁基-3-甲基咪唑-L-樟脑磺酸盐在无溶剂微波加热条件下可催化Biginelli反应合成monastrol,操作简单、耗时缩短、环境友好。 结论 以新型绿色室温离子液体1-丁基-3-甲基咪唑-L-樟脑磺酸盐为催化剂,经微波促进无溶剂Biginelli反应合成monastrol是一种操作简便、反应温和的绿色合成方法。 |
| 中文关键词:绿色室温离子液体 Monastrol Biginelli反应 1-丁基-3-甲基咪唑-L-樟脑磺酸盐 微波 |
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| Synthesis of monastrol catalyzed by 1-butyl-3-methylimidazolium (L)-camphorsulfonate |
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| Abstract:Objective To explore a convenient and environmentally friendly benign synthesis method of monastrol. Methods Monastrol was synthesized from m-hydroxybenzaldehyde, ethyl acetoacetate and thiourea through the Biginelli reaction catalyzed by 1-butyl-3-methylimidazolium (L)-camphorsulfonate under microwave irradiation without a solvent. Results The green room temperature ionic liquid could catalyze the Biginelli reaction to get monsatrol under microwave irradiation without a solvent. The process was easy to operate and was environmentally friendly. Conclusion Microwave accelerated solvent-free Biginelli reaction using 1-butyl-3-methylimidazolium (L)-camphorsulfonate as catalyst, which was a convenient and environmentally benign synthesis method of monastrol. |
| keywords:green room temperature ionic liquids monastrol Biginelli reaction 1-butyl-3-methylimidazolium (L)-camphorsulfonate |
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