| 钩藤总碱的热稳定性研究 |
| 投稿时间：2010-11-20 修订日期：2011-06-28 点此下载全文 |
| 引用本文：刘卫,杨雪萍,王中师,王盟,张强,郝立勇.钩藤总碱的热稳定性研究[J].药学实践杂志,2011,29(6):442~444 |
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| 基金项目:山东省科技发展计划项目(2008GG2NS02006). |
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| 中文摘要:目的 考察钩藤总碱的热稳定性。 方法 在不同温度条件下,用高效液相色谱检查钩藤总碱中的钩藤碱和异钩藤碱。 结果 与钩藤碱相比,异钩藤碱溶液对热不稳定,60 ℃或90 ℃ 2 h后异钩藤碱含量明显降低,而钩藤碱溶液在60 ℃ 2 h或4 ℃ 6 d的环境中稳定。而且,钩藤碱和异钩藤碱成盐后更加稳定。 结论 异钩藤碱的热不稳定性是钩藤"后下"的原因。 |
| 中文关键词:钩藤碱 异钩藤碱 钩藤总碱 |
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| Studies on thermal stability of total alkaloids in rhynchophylline |
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| Abstract:Objective To investigate the effect of heating on total alkaloids in rhynchphylla. Methods HPLC was employed to determine rhynchophylline and isorhynchophylline in total alkaloids among various conditions. Results Comparing with rhynchophylline, isorhynchophylline was unstable to heating. Heated in 60 ℃ and 90 ℃ for 2 hours, isorhynchophylline content decreased more than 38% and 50%, respectively. But rhynchophylline solution was stable in 60 ℃ for 2 hours and 4 ℃ for 6 days. In addition, rhynchophylline and isorhynchophylline were more stable in salt formation. Conclusion Isorhynchophylline was unstable to heating, which was the reason for rhynchophylla to given later.in decoct herbal medicine. |
| keywords:rhynchophylline isorhynchophylline rhynchphylla total alkaloids |
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