| 新型三唑醇类化合物的合成及抗真菌活性研究 |
| 投稿时间：2010-07-07 修订日期：2011-03-04 点此下载全文 |
| 引用本文：王曙东,陈兴东,赵庆杰,邹燕,胡宏岗,俞世冲,汪亭,柴晓云,任海祥.新型三唑醇类化合物的合成及抗真菌活性研究[J].药学实践杂志,2011,29(6):426~430 |
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| 基金项目:国家自然科学基金资助项目(20772153),上海市重点学科资助项目 (B906). |
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| 中文摘要:目的 以氟康唑为先导化合物,设计合成新的三唑醇类化合物,并研究其抗真菌活性。 方法 引入较大基团的N,N-二取代侧链结构,合成一系列目标化合物,所有化合物结构均经MS、1H NMR等谱确证;选择8种真菌为实验菌株,测定其体外抗真菌活性。 结果 合成了18 个未见文献报道的目标化合物,化合物对所选真菌均表现出了一定的抑菌活性。 结论 引入较大基团的N,N-二取代侧链结构对抗真菌活性影响较大。 |
| 中文关键词:三唑衍生物 合成 抗真菌活性 |
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| Synthesis and antifungal activity of the novel triazole compounds |
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| Abstract:Objective To design the synthesis and evaluate the antifungal active of the novel triazole compounds based on the structure of fluconazole. Methods The big N,N-disubstituted group was introduced and a series of compounds were synthesized, all of them were confirmed by MS and 1H NMR, et al. The antifungal activity were also evaluated against the eight common pathogenic fungi. Results Eighteen compounds were synthesized,which exhibited activity against fungi tested. Conclusion The big N,N-disubstituted group introduced to the side chain could affected the antifungal activity. |
| keywords:triazole derivatives synthesis antifungal activity |
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