| 载抗肿瘤药物纳米靶向给药系统的研究进展 |
| 投稿时间：2011-04-09 修订日期：2011-05-08 点此下载全文 |
| 引用本文：陈婷,鲁莹.载抗肿瘤药物纳米靶向给药系统的研究进展[J].药学实践杂志,2011,29(3):176~178,196 |
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| 中文摘要:利用纳米微粒作为小分子抗肿瘤药物靶向传递系统的研究正在快速的发展和进行中,将抗肿瘤药物用各种不同材料的纳米微粒包裹,可以有助于提高其水溶性,增加肿瘤组织中的药物分布,以及加强抗肿瘤活性,同时减小对其他组织器官的非特异性毒性。此类研究主要集中在如何使得抗肿瘤药物在靶向肿瘤组织部位释放传递以及限制其对健康组织器官的影响,本文从当今常见纳米载药系统的类型以及肿瘤细胞靶向、肿瘤微环境靶向以及肿瘤转移灶靶向等多方面综述载抗肿瘤药物纳米微粒传递系统的研究进展。 |
| 中文关键词:纳米粒 抗肿瘤药物 靶向治疗 |
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| Study on targeted nanoparticles for anticancer therapy |
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| Abstract:The delivery of chemotherapeutics with targeted nanoparticles in anticancer therapy was a rapidly growing area of research. The advantages of targeted nanoparticles for drug delivery include water solubility increasement, tumor-specific accumulation and antitumor efficacy improvement, and nonspecific toxicity reduction. Current research in this field focused on understanding precisely how small molecules were released from nanoparticles and deliver to the targeted tumor tissues or cells, and how the unique biodistribution of the drug-carrying nanoparticles limits toxicity in major organs. The existing nanoparticles for the delivery of small-molecule anticancer agents and recent advances in this field were discussed in this paper. |
| keywords:nanopaticles chemotherapeutics targeted therapy |
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