| 替硝唑果胶骨架型结肠定位缓释片在犬体内药动学研究 |
| 投稿时间：2010-04-26 修订日期：2010-06-18 点此下载全文 |
| 引用本文：刘福强,王艳萍,赵楠,王相阳,崔海珍.替硝唑果胶骨架型结肠定位缓释片在犬体内药动学研究[J].药学实践杂志,2010,28(5):363~365,368 |
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| 中文摘要:目的:研究替硝唑果胶骨架型结肠定位缓释片在犬体内药动学。方法:采用双周期交叉试验设计,6只健康Beagle犬分别服用受试制剂或参比制剂,用HPLC法测定Beagle犬血浆中药物浓度。结果:受试、参比制剂在犬体内的血药浓度变化符合二室模型,其主要药动学参数:Tmax分别为(7.0±0.92)和(2.0±0.31)h;Cmax分别为(66.97±5.9)和(112.2±7.4)μg/L;AUC0-t分别为(1 243.88±25.67)和(1 523.84±27.89)mg.h/L;AUC0-∞分别为(1 277.18±30.58)和(1 548.67±20.89)mg.h/L,受试制剂的相对生物利用度为82.47%。结论:本法准确、灵敏,适用于替硝唑果胶骨架型结肠定位缓释片的药动学研究。 |
| 中文关键词:替硝唑 果胶 骨架片 结肠定位缓释片 |
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| The pharmacokinetics study of tinidazole pectin matrics colon-specific sustained-release tablets in dogs |
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| Abstract:Objective To develop a method to study the pharmacokinetics of tinidazole pectin matrics colon-specific sustained-release tablets in dogs.Methods The plasma concentrations were determined by HPLC.Two-period cross over self-control trail was conducted to 6 Beagle dogs which were administrated a single dose of the oral test tablets and reference tablets.Results The pharmacokinetics of two preparations fitted to two-compartment model.The main pharmacokinetic parameters:Tmax were(7.0±0.92)and(2.0±0.31) h;Cmax were(66.97±5.9)and(112.2±7.4) μg/L;AUC0-t were(1 243.88±25.67)and(1 523.84±27.89) mg·h/L;AUC0-∞ were(1 277.18±30.58)and(1 548.67±20.89) mg·h/L and test tablets showed a relative bioavailability of 82.47%.Conclusion The method was accurate and sensitive which was suitable for Tinidazole pectin matrics pharmacokinetics study. |
| keywords:tinidazole pectin matrics tablets colon-specific sustained-release tablets |
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