舒肝安乐宁浸膏对小鼠急性肝损伤的保护作用

夏爱军; 张琪; 梁园

舒肝安乐宁浸膏对小鼠急性肝损伤的保护作用

投稿时间：2010-04-22 修订日期：2010-05-24 点此下载全文

引用本文：夏爱军,张琪,梁园.舒肝安乐宁浸膏对小鼠急性肝损伤的保护作用[J].药学实践杂志,2010,28(5):352~353,380

摘要点击次数: 1360

全文下载次数: 877

作者	单位
夏爱军	解放军第303医院药剂科,广西南宁530021
张琪	解放军第303医院药剂科,广西南宁530021
梁园	解放军第303医院药剂科,广西南宁530021

中文摘要:目的:研究舒肝安乐宁浸膏对四氯化碳(CCl₄)诱导的小鼠急性化学性肝损伤的保护作用。方法:采用CCl₄制备小鼠急性化学性肝损伤模型,测定血清中丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)活性,肝组织中谷胱甘肽(GSH)、丙二醛(MDA)水平及谷胱甘肽过氧化酶(GSH-Px)活性,分析舒肝安乐宁浸膏对上述指标的影响。结果:舒肝安乐宁浸膏各剂量组均能升高急性化学性肝损伤小鼠肝组织GSH、GSH-Px含量(P<0.01),降低血清ALT、AST活性(P<0.05或P<0.01)与肝组织MDA含量(P<0.05)。结论:舒肝安乐宁浸膏对CCl₄所致小鼠急性化学性肝损伤具有明显的保护作用,这可能与增强谷胱甘肽系统抗氧化能力有关。

中文关键词:舒肝安乐宁浸膏四氯化碳肝损伤

Hepatoprotective effect of Shugananlening extract against acute hepatic injury in mice

Abstract:Objective To study the hepatoprotective effect of shugananlening extract against mice liver damage which induced by carbon tetrachloride(CCl₄).Methods Acute chemical liver jnjury model was induced by CCl₄ in mice.The activities of ALT,AST in serum and the content of MDA,GSH,GSH-Px in liver were measured.Results Different dose of shugananlening extract significantly increased the content of GSH,GSH-Px in liver(P<0.01),decreased the activities of ALT,AST in serum and content of MDA in liver(P<0.05).Conclusion Shugananlening extract has a good protective effect on acute chemical liver injury in mice,which possibly due to the antioxidative capability of strengthening GSH system.

keywords:shugananlening extract carbon tetrachloride(CCl₄) acute hepatic injury

查看全文查看/发表评论下载PDF阅读器

关闭